Naslov
Changes in serum levels of inflammatory biomarkers in patients with acute and chronic coronary syndrome consuming n-3 polyunsaturated fatty acid enriched hen eggs - a randomized study

Autori
Drenjančević, Ines ; Stupin, Ana ; Mihaljević, Zrinka ; Breškić Ćurić, Željka ; Masle, Ana Marija ; Kibel, Aleksandar ; Selthofer-Relatić, Kristina ; Jukić, Ivana ; Stupin, Marko ; Matić, Anita ; Kozina, Natasa ; Šušnjara, Petar ; Juranić, Brankica ; Kolobarić, Nikolina ; Šerić, Vatroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Annual meeting of the Croatian Immunological Society 2021, Abstract book / - , 2021, 40-40

Skup
Annual Meeting of the Croatian Immunological Society 2021

Mjesto i datum
Trogir, Hrvatska, 22.09.2021. - 25.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
n-3 PUFAs ; functional food ; coronary syndrome ; inflammatory biomarkers

Sažetak
There is a strong potential of n-3 polyunsaturated fatty acids (n-3 PUFAs) consumption to reduce cardiovascular risk and to prevent adverse outcomes in existing cardiovascular diseases. This study aimed to test if dietary supplementation of n-3 PUFAs in form of enriched hen eggs may modulate serum lipid and fatty acid profile, inflammatory and oxidative stress biomarkers in patients with coronary artery disease (CAD). Forty CAD patients participated in this study ; 20 patients had acute CAD (Ac- CAD) and 20 patients had chronic CAD (Ch-CAD). Control group (N=20) ate three regular hens’ eggs/daily (249mg n-3 PUFAs/day), and n-3 PUFAs group (N=20) ate three n-3 PUFAs enriched hen eggs/daily (1053mg n-3 PUFAs/day) for 3 weeks. Serum n-3 PUFAs concentration significantly increased (in all CAD patients), while total cholesterol and LDL cholesterol and IL-6 (in Ac-CAD patients), as well as total cholesterol and LDL, hsCRP and IL-1a (in all CAD patients) significantly decreased in n-3 PUFAs group. Glutathione peroxidase (GPx) activity significantly decreased. Consumption of three n- 3 PUFAs enriched hen eggs for three weeks have favorable effect on fatty acids profile (lower n-6/n-3 PUFAs ratio) and mild anti-inflammatory effect. Since consumption of both regular and n-3 PUFAs eggs had no negative effects on any of the measured parameters, results of the present study also indicate that eggs can be safely consumed in the daily diet of patients with coronary artery disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Acknowledgement: Results are published in: Ćurić Breškić Ž,
Masle AM, Kibel A, Selthofer-Relatić K, Stupin A, Mihaljević Z,
Jukić I, Stupin M, Matić A, Kozina N, Šušnjara P, Juranić B,
Kolobarić N, Šerić V, Drenjančević I. Biology (Basel). 2021 Aug
14;10(8):774. doi: 10.3390/biology10080774. Funding: This
research was supported by the European Structural and Investment
Funds grant for the Croatian National Scientific Center of
Excellence for Personalized Health Care, University of Josip
Juraj Strossmayer Osijek (grant #KK.01.1.1.01.0010).

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