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Pregled bibliografske jedinice broj: 1146059

MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

Landoni, Giovanni; Lomivorotov, Vladimmir; Pisano, Antonio; Nigro Neto, Caetano; Benedetto, Umberto; Biondi Zoccai, Giuseppe; Gemma, Marco; Frassoni, Samuele; Agrò, Felice Eugenio; Baiocchi, Massimo et al.
MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design // Contemporary clinical trials, 59 (2017), 38-43 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1146059 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

Autori
Landoni, Giovanni ; Lomivorotov, Vladimmir ; Pisano, Antonio ; Nigro Neto, Caetano ; Benedetto, Umberto ; Biondi Zoccai, Giuseppe ; Gemma, Marco ; Frassoni, Samuele ; Agrò, Felice Eugenio ; Baiocchi, Massimo ; Barbosa Gomes Galas, Filomena ; Bautin, Andrei ; Bradic, Nikola ; Carollo, Cristiana ; Crescenzi, Giuseppe ; Elnakera, Abeer ; El-Tahan, Mohamed ; Fominskiy, Evgeny ; Farag, Ahmed ; Gazivoda, Gordana ; Gianni, Stefano ; Grigoryev, Evgeny ; Guarracino, Fabio ; Hanafi, Sidik ; Huang, Weiqing ; Kunst, Gudrun ; Kunstyr, Jan ; Lei, Chong ; Lembo, Rosalba ; Li, Zhi-Jian ; Likhvantsev, Valery ; Lozovskiy, Andrey ; Ma, Jun ; Monaco, Fabrizio ; Navalesi, Paolo ; Nazar, Bukamal ; Pasyuga, Vadim ; Porteri, Elena ; Royse, Colin ; Ruggeri, Laura ; Riha, Hynek ; , Santos Silva, Fernanda ; Severi, Luca ; Shmyrev, Vladimir ; Uvaliev, Nikolay ; Wang, Cheng Bin ; Wang, Chew-Yin ; Winterton, Dario ; Yong, Chow-Yen ; Yu, Jingui ; Bellomo, Rinaldo ; Zangrillo, Alberto

Izvornik
Contemporary clinical trials (1551-7144) 59 (2017); 38-43

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cardiac anesthesia ; Cardiac surgery ; Intensive care ; Randomized trial ; Total intravenous anesthesia ; Volatile anesthetics

Sažetak
Objective: There is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable. Design: Single blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio. Setting: Tertiary and University hospitals. Interventions: Patients (n=10, 600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia. Measurements and main results: The primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality ; 30-day death or non-fatal myocardial infarction (composite endpoint) ; cardiac mortality at 30day and at one year ; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two- sided alpha error of 0.05, and a power of 0.9. Conclusions: The trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Klinička bolnica "Dubrava",
Sveučilište Sjever, Koprivnica

Profili:

Avatar Url Nikola Bradić (autor)

Citiraj ovu publikaciju:

Landoni, Giovanni; Lomivorotov, Vladimmir; Pisano, Antonio; Nigro Neto, Caetano; Benedetto, Umberto; Biondi Zoccai, Giuseppe; Gemma, Marco; Frassoni, Samuele; Agrò, Felice Eugenio; Baiocchi, Massimo et al.
MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design // Contemporary clinical trials, 59 (2017), 38-43 (međunarodna recenzija, članak, znanstveni)
Landoni, G., Lomivorotov, V., Pisano, A., Nigro Neto, C., Benedetto, U., Biondi Zoccai, G., Gemma, M., Frassoni, S., Agrò, F. & Baiocchi, M. (2017) MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design. Contemporary clinical trials, 59, 38-43.
@article{article, author = {Landoni, Giovanni and Lomivorotov, Vladimmir and Pisano, Antonio and Nigro Neto, Caetano and Benedetto, Umberto and Biondi Zoccai, Giuseppe and Gemma, Marco and Frassoni, Samuele and Agr\`{o}, Felice Eugenio and Baiocchi, Massimo and Barbosa Gomes Galas, Filomena and Bautin, Andrei and Bradic, Nikola and Carollo, Cristiana and Crescenzi, Giuseppe and Elnakera, Abeer and El-Tahan, Mohamed and Fominskiy, Evgeny and Farag, Ahmed and Gazivoda, Gordana and Gianni, Stefano and Grigoryev, Evgeny and Guarracino, Fabio and Hanafi, Sidik and Huang, Weiqing and Kunst, Gudrun and Kunstyr, Jan and Lei, Chong and Lembo, Rosalba and Li, Zhi-Jian and Likhvantsev, Valery and Lozovskiy, Andrey and Ma, Jun and Monaco, Fabrizio and Navalesi, Paolo and Nazar, Bukamal and Pasyuga, Vadim and Porteri, Elena and Royse, Colin and Ruggeri, Laura and Riha, Hynek and Severi, Luca and Shmyrev, Vladimir and Uvaliev, Nikolay and Wang, Cheng Bin and Wang, Chew-Yin and Winterton, Dario and Yong, Chow-Yen and Yu, Jingui and Bellomo, Rinaldo and Zangrillo, Alberto}, year = {2017}, pages = {38-43}, keywords = {Cardiac anesthesia, Cardiac surgery, Intensive care, Randomized trial, Total intravenous anesthesia, Volatile anesthetics}, journal = {Contemporary clinical trials}, volume = {59}, issn = {1551-7144}, title = {MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design}, keyword = {Cardiac anesthesia, Cardiac surgery, Intensive care, Randomized trial, Total intravenous anesthesia, Volatile anesthetics} }
@article{article, author = {Landoni, Giovanni and Lomivorotov, Vladimmir and Pisano, Antonio and Nigro Neto, Caetano and Benedetto, Umberto and Biondi Zoccai, Giuseppe and Gemma, Marco and Frassoni, Samuele and Agr\`{o}, Felice Eugenio and Baiocchi, Massimo and Barbosa Gomes Galas, Filomena and Bautin, Andrei and Bradic, Nikola and Carollo, Cristiana and Crescenzi, Giuseppe and Elnakera, Abeer and El-Tahan, Mohamed and Fominskiy, Evgeny and Farag, Ahmed and Gazivoda, Gordana and Gianni, Stefano and Grigoryev, Evgeny and Guarracino, Fabio and Hanafi, Sidik and Huang, Weiqing and Kunst, Gudrun and Kunstyr, Jan and Lei, Chong and Lembo, Rosalba and Li, Zhi-Jian and Likhvantsev, Valery and Lozovskiy, Andrey and Ma, Jun and Monaco, Fabrizio and Navalesi, Paolo and Nazar, Bukamal and Pasyuga, Vadim and Porteri, Elena and Royse, Colin and Ruggeri, Laura and Riha, Hynek and Severi, Luca and Shmyrev, Vladimir and Uvaliev, Nikolay and Wang, Cheng Bin and Wang, Chew-Yin and Winterton, Dario and Yong, Chow-Yen and Yu, Jingui and Bellomo, Rinaldo and Zangrillo, Alberto}, year = {2017}, pages = {38-43}, keywords = {Cardiac anesthesia, Cardiac surgery, Intensive care, Randomized trial, Total intravenous anesthesia, Volatile anesthetics}, journal = {Contemporary clinical trials}, volume = {59}, issn = {1551-7144}, title = {MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design}, keyword = {Cardiac anesthesia, Cardiac surgery, Intensive care, Randomized trial, Total intravenous anesthesia, Volatile anesthetics} }

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