Pregled bibliografske jedinice broj: 114575
Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system
Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system // Journal of Controlled Release, 88 (2003), 381-391 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 114575 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system
Autori
Grassi, Mario ; Voinovich, Dario ; Moneghini, Mariarosa ; Franceschinis, Erica ; Perissutti, Beatrice, Filipović-Grčić, Jelena
Izvornik
Journal of Controlled Release (0168-3659) 88
(2003);
381-391
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
melt pelletisation; high shear mixer; paracetamol; sustained release; modelling of drug-release mechanism
Sažetak
The potential of a sustained release formulation for paracetamol produced by melt pelletisation was investigated. The chosen formulation was based on the combination of stearic acid as a melting binder and anhydrous lactose as a filler. After determination of the size distribution, the pellet characterisation included scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), specific surface area and true density determination. Hence, the in vitro release from every single size fraction (2000, 1250, 800, 630, < 630 um) was evaluated and the release mechanism was analysed with the help of an appropriate mathematical model.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
