Naslov
Shifting perspectives – interplay between non- alcoholic fatty liver disease and insulin resistance in lean individuals

Autori
Bilić-Curcić, Ines ; Cigrovski Berković, Maja ; Virović- Jukić, Lucija ; Mrzljak, Anna

Izvornik
World journal of hepatology (1948-5182) 13 (2021), 1; 80-93

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Non-alcoholic fatty liver disease ; Metabolic phenotype ; Lean individuals ; Insulin resistance ; Visceral fat tissue ; Sarcopenia

Sažetak
Non-alcoholic fatty liver disease (NAFLD) has become a significant public health burden affecting not only obese individuals but also people with normal weight. As opposed to previous beliefs, this particular subset of patients has an increased risk of all-cause mortality and worse outcomes than their obese counterparts. The development of NAFLD in lean subjects seems to be interconnected with metabolic phenotype, precisely visceral fat tissue, sarcopenia, and insulin resistance. Here, we summarize available data focusing on the co-dependent relationship between metabolic phenotype, insulin resistance, and development of NAFLD in lean individuals, suggesting more appropriate tools for measuring body fat distribution for the screening of patients at risk.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA