Pregled bibliografske jedinice broj: 1145123
Hypothyroidism and pregnancy: still a controversial issue
Hypothyroidism and pregnancy: still a controversial issue // Gynecological Endocrinology, 36 (2020), 9; 776-780 doi:10.1080/09513590.2020.1740202 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1145123 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Hypothyroidism and pregnancy: still a
controversial issue
Autori
Cigrovski Berković, Maja ; Herman Mahečić, Davorka ; Marinković Radošević, Jelena ; Strinović Morić, Mateja ; Bilić-Ćurčić, Ines
Izvornik
Gynecological Endocrinology (0951-3590) 36
(2020), 9;
776-780
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Overt hypothyroidism ; subclinical hypothyroidism ; pregnancy outcomes ; TPO-antibody ; Tg-antibody ; levothyroxine substitution
(egnancy outcomes ; TPO-antibody ; Tg-antibody ; levothyroxine substitution)
Sažetak
Subclinical hypothyroidism (SCH) in pregnancy is common, according to literature, affecting up to 15% of pregnancies. It still represents a controversy weather levothyroxine has beneficial effects on pregnancy outcomes. In this retrospective and prospective cohort study, we assessed fetal and maternal outcomes in women with known thyroid status pre- pregnancy, and hypothyroidism during pregnancy. We included 393 pregnant women, 90 (22.9%) diagnosed with overt and 303 with SCH (77.1%). A total of 94 (56%) had positive anti-TPO antibodies. Levothyroxine substitution across all observational periods was suboptimal, mostly during first trimester in both groups of patients (85.4%). There was a difference in the number of live births in favor of group with SCH (p = .004). Women with overt hypothyroidism were more likely to develop complications during pregnancy (RR = 1.153, 95%CI = 0.775 − 1.714) and had positive TPO-antibodies more often (p = .022). The only significant association was found between fetal outcomes in women with SCH and positive TPO-antibodies (p = .018), while positive Tg-antibodies did not affect the pregnancy outcomes of women with SCH. Moreover, no correlation was observed between outcomes and adequacy of levothyroxine substitution. These results indicate that TPO- antibody positivity could be the most important factor of pregnancy outcomes independent of the TSH levels or adequacy of levothyroxine therapy.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Kineziološki fakultet, Zagreb,
KBC "Sestre Milosrdnice"
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
