Naslov
Serological markers of inflammatory bowel disease

Autori
Tešija Kuna, Andrea

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), stručni

Izvornik
New trends in classification, monitoring and management of gastrointestinal diseases / Topić, E - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2012, 107-121

Skup
The 12th EFLM Continuous Postgraduate Course in Clinical Chemistry

Mjesto i datum
Dubrovnik, Hrvatska, 10.11.2012. - 11.11.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Inflammatory bowel disease ; Colitis ulcerative ; Crohn disease ; Serological tests
(inflammatory bowel disease ; colitis ulcerative ; Crohn disease ; serological tests)

Sažetak
The spectrum of antibodies to different microbial antigens and autoantibodies associated with IBD is rapidly expanding. Most of these antibodies are associated with CD like anti-glycan antibodies: anti-Saccharomices cerevisiae (ASCA) and the recently described anti-laminaribioside (ALCA), anti-chitobioside (ACCA), anti-mannobioside (AMCA), anti- laminarin (anti-L) and anti-chitin (anti-C) antibodies ; in addition to other antibodies that target microbial antigens: anti-outer membrane porin C (anti-OmpC), anti-Cbir1 flagellin and anti-I2 antibody. Also, autoantibodies targeting the exocrine pancreas (PAB) were shown to be highly specific for CD. In contrast, UC has been associated with anti- neutrophil cytoplasmic autoantibodies (pANCA) and antibodies against goblet cells (GAB). Current evidence suggests that serologic panels of multiple antibodies are useful in differential diagnosis of CD versus UC and can be a valuable aid in stratifying patients according to disease phenotype and risk of complications.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA