Naslov
Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Autori
Tan, Jia Ying Brenda ; Yoon, Bo Kyeong ; Cho, Nam-Joon ; Lovrić, Jasmina ; Jug, Mario ; Jackman, Joshua Alexander

Izvornik
International journal of molecular sciences (1422-0067) 22 (2021), 18; 9664, 27

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
fatty acid ; monoglyceride ; lipid nanoparticle ; liposome ; bicelle ; solid lipid nanoparticle ; nanostructured lipid carrier ; nanoemulsion ; lipid nanocapsule ; polymeric micelle

Sažetak
There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane- related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

Napomena
This research was supported by the International Research & Development Program of the National
Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT 2020K1A3A1A39112724).

POVEZANOST RADA