Pregled bibliografske jedinice broj: 1141934
Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines
Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines // Molecular Cytogenetics, 13 (2020), 43, 10 doi:10.1186/s13039-020-00511-4 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1141934 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines
Autori
Wahlbuhl, Eva ; Liehr, Thomas ; Rinčić, Martina ; Azawi, Shaymaa
Izvornik
Molecular Cytogenetics (1755-8166) 13
(2020);
43, 10
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
AB1 ; AB22 ; AC29 ; array comparative genomic hybridization (aCGH) ; malignant mesothelioma ; murine cell line ; murine multicolor banding (mcb)
(AB1 ; AB22 ; AC29 ; array comparative genomic hybridization (aCGH) ; malignant mesothelioma ; murine cell line ; murine multicolor banding (mcb).)
Sažetak
Background: Malignant mesothelioma (MM) is a rare aggressive cancer primary located in pleura and lung. MMs can be divided into biphasic, epithelioid and sarcomatoid subtypes. In majority of cases MMs are induced by asbestos fiber exposure. As latency period after asbestos exposure ranges between ~ 10 and 60 years MMs are mainly observed in elder people. Human MM, being a rare tumor type, lacks detailed cytogenetic data, while molecular genetic studies have been undertaken more frequently. However, murine MM cell lines are also regularly applied to get more insight into MM biology and to test new therapy strategies. Results: Here the murine MM cell lines AB1, AB22 and AC29 were studied by molecular cytogenetics and molecular karyotyping. Interestingly, yet there were no genetic or genomic studies undertaken for these already in 1992 established cell lines. The obtained data on genomic imbalances in these murine cell lines was translated into the human genome as previously reported based on human and murine genomic browsers. Conclusions: It turned out that all three cell lines showed high similarities in copy number variants as observed typically in human MM. Also, all three cell lines were most similar to human epithelioid MMs, and should be used as models therefore.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
