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Pregled bibliografske jedinice broj: 1141413

Cardiac Pacemaker Exposed to Electroporation Pulses – An Ex Vivo Study

Jarm, Tomaz; Krmac, Tadej; Miklavcic, Damijan; Magjarevic, Ratko
Cardiac Pacemaker Exposed to Electroporation Pulses – An Ex Vivo Study // 15th Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON)
Coimbra, Portugal: Springer, 2019. str. 439-446 doi:10.1007/978-3-030-31635-8_53 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)

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Naslov
Cardiac Pacemaker Exposed to Electroporation Pulses – An Ex Vivo Study

Autori
Jarm, Tomaz ; Krmac, Tadej ; Miklavcic, Damijan ; Magjarevic, Ratko

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Skup
15th Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON)

Mjesto i datum
Coimbra, Portugal, 26.09.2019. - 28.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Electroporation ; Electrochemotherapy ; Cardiac pacemaker ; Safety

Sažetak
Electrochemotherapy (ECT) consists of administration of a chemotherapeutic drug followed by local application of high-voltage electroporation (EP) pulses and is a well-proven method for treatment of various types of tumors. However, as a precaution ECT of deep-seated internal tumors is contraindicated in patients with implanted cardiac pacemakers. To address this limitation a functioning pacemaker programmed in asynchronous D00 mode with the ventricular and atrial leads connected was exposed to EP pulses in a conductive medium mimicking the conditions encountered in clinical setting. EP pulses were generated by the Cliniporator Vitae device and delivered via electrodes for clinical ECT. Application of EP pulses was synchronized with different phases of the pacing cycle, including the potentially most vulnerable phase, the pacing pulse itself. The effects on pacemaker operation were investigated by recording the voltages between the cathode and the anode of the bipolar ventricular lead. EP pulses induced large artefacts far exceeding the amplitude of the pacing pulse itself. This was followed by transiently disrupted shape of the remaining portion of the pacing pulse. However, all effects were strictly limited to this single pacing pulse. No effects at all were observed in subsequent pacing pulses. The pacemaker and its function remained completely immune to electroporation pulses delivered outside the pacing pulse itself.

Izvorni jezik
Engleski

Znanstvena područja
Elektrotehnika, Interdisciplinarne tehničke znanosti



POVEZANOST RADA

Ustanove:
Fakultet elektrotehnike i računarstva, Zagreb

Profili:

Avatar Url Ratko Magjarević (autor)

Poveznice na cjeloviti tekst rada:

doi www.springerprofessional.de

Citiraj ovu publikaciju:

Jarm, Tomaz; Krmac, Tadej; Miklavcic, Damijan; Magjarevic, Ratko
Cardiac Pacemaker Exposed to Electroporation Pulses – An Ex Vivo Study // 15th Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON)
Coimbra, Portugal: Springer, 2019. str. 439-446 doi:10.1007/978-3-030-31635-8_53 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
Jarm, T., Krmac, T., Miklavcic, D. & Magjarevic, R. (2019) Cardiac Pacemaker Exposed to Electroporation Pulses – An Ex Vivo Study. U: 15th Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON) doi:10.1007/978-3-030-31635-8_53.
@article{article, author = {Jarm, Tomaz and Krmac, Tadej and Miklavcic, Damijan and Magjarevic, Ratko}, year = {2019}, pages = {439-446}, DOI = {10.1007/978-3-030-31635-8\_53}, keywords = {Electroporation, Electrochemotherapy, Cardiac pacemaker, Safety}, doi = {10.1007/978-3-030-31635-8\_53}, title = {Cardiac Pacemaker Exposed to Electroporation Pulses – An Ex Vivo Study}, keyword = {Electroporation, Electrochemotherapy, Cardiac pacemaker, Safety}, publisher = {Springer}, publisherplace = {Coimbra, Portugal} }
@article{article, author = {Jarm, Tomaz and Krmac, Tadej and Miklavcic, Damijan and Magjarevic, Ratko}, year = {2019}, pages = {439-446}, DOI = {10.1007/978-3-030-31635-8\_53}, keywords = {Electroporation, Electrochemotherapy, Cardiac pacemaker, Safety}, doi = {10.1007/978-3-030-31635-8\_53}, title = {Cardiac Pacemaker Exposed to Electroporation Pulses – An Ex Vivo Study}, keyword = {Electroporation, Electrochemotherapy, Cardiac pacemaker, Safety}, publisher = {Springer}, publisherplace = {Coimbra, Portugal} }

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