Naslov
Mast cell leukemia--case report

Autori
Vasilj, Ankica ; Kojić Katović, Sandra ; Maričević, Ivana ; Zokvić, Edita ; Gaćina, Petar

Izvornik
Acta medica Croatica (1330-0164) 67 (2013), 1; 61-64

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
mastocitoze ; mastocitna leukemija ; citokemija ; imunocitokemija
(aged ; biopsy ; bone marrow pathology ; female ; humans ; leukemia, mast-cell diagnosis ; leukemia, mast-Cell pathology ; leukemia, mast-cell therapy ; mast cells pathology ; mastocytosis complications)

Sažetak
Mast cell leukemia is extremely rare, more often arises de novo and in 15% of cases developes from preexistence mast cell diseases. It is a high malignant leukemia with bad prognosis and a short survival. A 72-year old female was admitted to hospital with clinically suspected plasmocytoma. She had eccematoid changes on her trunk and underarms. Radiogramm showed osteolytic lesions of the right thigh and pelvis. FNA of the bone marrow revealed hypercellular smear with 80% of mast cells and immature mast cells which were cytochemically positive to toluidin (Figure 1. and 2.), chloracetate, alcian blue, acid fosphatase and Sudan black and negative to periodic acid Schiff (PAS) and peroxidase (POX). The peripheral blood smear showed single mast cells which were positive to toluidin. The bone marrow biopsy confirmed mast cell leukemia. The chariogramm of the bone marrow showed numerical and structural chromosomal changes. Two month after the diagnosis the patient suffered from right thigh fracture and was treated with local radiotherapy, antihistaminic and analgetic therapy. The patient died within 6 month after the diagnosis.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA