Naslov
Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression

Autori
Uher, Rudolf ; Maier, Wolfgang ; Hauser, Joanna ; Marušič, Andrej ; Schmael, Christine ; Mors, Ole ; Henigsberg, Neven ; Souery, Daniel ; Placentino, Anna ; Rietschel, Marcella ; Zobel, Astrid ; Dmitrzak-Weglarz, Monika ; Petrovic, Ana ; Jorgensen, Lisbeth ; Kalember, Petra ; Giovannini, Caterina ; Barreto, Mara ; Elkin, Amanda ; Landau, Sabine ; Farmer, Anne ; Aitchison, Katherine J. ; McGuffin, Peter

Izvornik
British journal of psychiatry (0007-1250) 194 (2009), 3; 252-259

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
efficacy ; escitalopram ; nortryptiline ; depression

Sažetak
Background Tricyclic antidepressants and serotonin reuptake inhibitorsare considered to be equally effective, but differences may have been obscured by internally inconsistent measurement scales and inefficient statistical analyses. Aims To test the hypothesis that escitalopram and nortriptyline differ in their effects on observed mood, cognitive and neurovegetative symptoms of depression. Method In a multicentre part-randomised open-label design (the Genome Based Therapeutic Drugs for Depression (GENDEP) study) 811 adults with moderate to severe unipolar depression were allocated to flexible dosage escitalopram or nortriptyline for 12 weeks. The weekly Montgomery–A˚ sberg Depression Rating Scale, Hamilton Rating Scale for Depression, and Beck Depression Inventory were scored both conventionally and in a more novel way according to dimensions of observed mood, cognitive symptoms and neurovegetative symptoms. Results Mixed-effect linear regression showed no difference between escitalopram and nortriptyline on the three original scales, but symptom dimensions revealed drug-specific advantages. Observed mood and cognitive symptoms improved more with escitalopram than with nortriptyline. Neurovegetative symptoms improved more with nortriptyline than with escitalopram. Conclusions The three symptom dimensions provided sensitive descriptors of differential antidepressant response and enabled identification of drug- specific effects.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA