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Pregled bibliografske jedinice broj: 1139337

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies

Fabbri, Chiara; Tansey, Katherine E.; Perlis, Roy H.; Hauser, Joanna; Henigsberg, Neven; Maier, Wolfgang; Mors, Ole; Placentino, Anna; Rietschel, Marcella; Souery, Daniel et al.
Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies // European neuropsychopharmacology, 28 (2018), 8; 945-954 doi:10.1016/j.euroneuro.2018.05.009 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1139337 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies

Autori
Fabbri, Chiara ; Tansey, Katherine E. ; Perlis, Roy H. ; Hauser, Joanna ; Henigsberg, Neven ; Maier, Wolfgang ; Mors, Ole ; Placentino, Anna ; Rietschel, Marcella ; Souery, Daniel ; Breen, Gerome ; Curtis, Charles ; Lee, Sang-Hyuk ; Newhouse, Stephen ; Patel, Hamel ; O'Donovan, Michael ; Lewis, Glyn ; Jenkins, Gregory ; Weinshilboum, Richard M. ; Farmer, Anne ; Aitchison, Katherine J. ; Craig, Ian ; McGuffin, Peter ; Schruers, Koen ; Biernacka, Joanna M. ; Uher, Rudolf ; Lewis, Cathryn M.

Izvornik
European neuropsychopharmacology (0924-977X) 28 (2018), 8; 945-954

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CYP2C19 ; Gene ; Antidepressant ; Response ; Side effects ; Major depression

Sažetak
Cytochrome (CYP) P450 enzymes have a primary role in antidepressant metabolism and variants in these polymorphic genes are targets for pharmacogenetic investigation. This is the first meta- analysis to investigate how CYP2C19 polymorphisms predict citalopram/escitalopram efficacy and side effects. CYP2C19 metabolic phenotypes comprise poor metabolizers (PM), intermediate and intermediate + metabolizers (IM ; IM + ), extensive and extensive + metabolizers (EM [wild type] ; EM + ) and ultra- rapid metabolizers (UM) defined by the two most common CYP2C19 functional polymorphisms (rs4244285 and rs12248560) in Caucasians. These polymorphisms were geno- typed or imputed from genome-wide data in four samples treated with citalopram or escitalo- pram (GENDEP, STAR ∗D, GenPod, PGRN- AMPS). Treatment efficacy was assessed by standardized percentage symptom improvement and by remission. Side effect data were available at weeks 2–4, 6 and 9 in three samples. A fixed- effects meta-analysis was performed using EM as the reference group. Analysis of 2558 patients for efficacy and 2037 patients for side effects showed that PMs had higher symptom improvement (SMD = 0.43, CI = 0.19–0.66) and higher remission rates (OR = 1.55, CI = 1.23–1.96) compared to EMs. At weeks 2–4, PMs showed higher risk of gastro- intestinal (OR = 1.26, CI = 1.08–1.47), neurological (OR = 1.28, CI = 1.07–1.53) and sexual side effects (OR = 1.52, CI = 1.23–1.87 ; week 6 values were similar). No difference was seen at week 9 or in total side effect burden. PMs did not have higher risk of dropout at week 4 compared to EMs. Antidepressant dose was not different among CYP2C19 groups. CYP2C19 polymorphisms may provide helpful information for guiding citalopram/escitalopram treatment, despite PMs being relatively rare among Caucasians ( ∼2%).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Neven Henigsberg (autor)

Poveznice na cjeloviti tekst rada:

doi www.clinicalkey.com

Citiraj ovu publikaciju:

Fabbri, Chiara; Tansey, Katherine E.; Perlis, Roy H.; Hauser, Joanna; Henigsberg, Neven; Maier, Wolfgang; Mors, Ole; Placentino, Anna; Rietschel, Marcella; Souery, Daniel et al.
Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies // European neuropsychopharmacology, 28 (2018), 8; 945-954 doi:10.1016/j.euroneuro.2018.05.009 (međunarodna recenzija, članak, znanstveni)
Fabbri, C., Tansey, K., Perlis, R., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M. & Souery, D. (2018) Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies. European neuropsychopharmacology, 28 (8), 945-954 doi:10.1016/j.euroneuro.2018.05.009.
@article{article, author = {Fabbri, Chiara and Tansey, Katherine E. and Perlis, Roy H. and Hauser, Joanna and Henigsberg, Neven and Maier, Wolfgang and Mors, Ole and Placentino, Anna and Rietschel, Marcella and Souery, Daniel and Breen, Gerome and Curtis, Charles and Lee, Sang-Hyuk and Newhouse, Stephen and Patel, Hamel and O'Donovan, Michael and Lewis, Glyn and Jenkins, Gregory and Weinshilboum, Richard M. and Farmer, Anne and Aitchison, Katherine J. and Craig, Ian and McGuffin, Peter and Schruers, Koen and Biernacka, Joanna M. and Uher, Rudolf and Lewis, Cathryn M.}, year = {2018}, pages = {945-954}, DOI = {10.1016/j.euroneuro.2018.05.009}, keywords = {CYP2C19, Gene, Antidepressant, Response, Side effects, Major depression}, journal = {European neuropsychopharmacology}, doi = {10.1016/j.euroneuro.2018.05.009}, volume = {28}, number = {8}, issn = {0924-977X}, title = {Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies}, keyword = {CYP2C19, Gene, Antidepressant, Response, Side effects, Major depression} }
@article{article, author = {Fabbri, Chiara and Tansey, Katherine E. and Perlis, Roy H. and Hauser, Joanna and Henigsberg, Neven and Maier, Wolfgang and Mors, Ole and Placentino, Anna and Rietschel, Marcella and Souery, Daniel and Breen, Gerome and Curtis, Charles and Lee, Sang-Hyuk and Newhouse, Stephen and Patel, Hamel and O'Donovan, Michael and Lewis, Glyn and Jenkins, Gregory and Weinshilboum, Richard M. and Farmer, Anne and Aitchison, Katherine J. and Craig, Ian and McGuffin, Peter and Schruers, Koen and Biernacka, Joanna M. and Uher, Rudolf and Lewis, Cathryn M.}, year = {2018}, pages = {945-954}, DOI = {10.1016/j.euroneuro.2018.05.009}, keywords = {CYP2C19, Gene, Antidepressant, Response, Side effects, Major depression}, journal = {European neuropsychopharmacology}, doi = {10.1016/j.euroneuro.2018.05.009}, volume = {28}, number = {8}, issn = {0924-977X}, title = {Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies}, keyword = {CYP2C19, Gene, Antidepressant, Response, Side effects, Major depression} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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