Naslov
The onset of ulcerative colitis upon Helicobacter pylori eradication in a 72-year-old woman: report of a rare case with a 3-year follow-up

Autori
Homolak, Jan ; Nikolić, Marko ; Potoč, Dunja ; Živković, Mario ; Bakula, Dean ; Budimir, Ivan ; Pavić, Ivana ; Hrabar, Davor ; Ljubičić, Neven ; Vražić, Domagoj

Izvornik
Bmc gastroenterology (1471-230X) 21 (2021), 1; 303, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
case report ; helicobacter pylori ; ulcerative colitis ; inflammatory bowel disease ; golimumab

Sažetak
Background Epidemiological studies suggest an inverse association between H. pylori infection/exposure and inflammatory bowel disease prevalence/incidence, however, there are no reports of individual patients who developed a "non-transient” ulcerative colitis (UC) following H. pylori eradication. Case presentation We report a case of a 72-year-old female with an elderly- onset UC developed upon H. pylori eradication and a 3-year follow-up of the progression to steroid- dependent colitis complicated with enteropathic arthritis and final containment of the disease with golimumab. In our patient, H. pylori eradication was associated with the development of pancolitis that evolved into clinically, endoscopically, and pathohistologically confirmed UC. Conclusions The case of our patient provides a unique clinical context for a growing body of literature suggesting molecular mechanisms involved in the interaction of genes, environment, and microbiota to be of critical importance in the etiopathogenesis of UC, and thus, provides a valuable set of complementary translational information for preclinical and epidemiological research on the topic.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA