Naslov
TEX264 at the intersection of autophagy and DNA repair

Autori
Fielden, John ; Popović, Marta ; Ramadan, Kristijan

Izvornik
Autophagy (1554-8627) 18 (2021), 1; 40-49

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
TEX264 ; autophagy ; DNA repair ; GyrI proteins ; p97

Sažetak
TEX264 (testes expressed gene 264) is a single pass transmembrane protein, consisting of an N-terminal hydrophobic region, a gyrase inhibitory (GyrI)-like domain, and a loosely structured C terminus. TEX264 was first identified as an endoplasmic reticulum (ER)-resident Atg8-family binding protein that mediates the degradation of portions of the ER during starvation (i.e., reticulophagy). More recently, TEX264 was identified as a cofactor of VCP/p97 ATPase that promotes the repair of covalently trapped TOP1 (DNA topoisomerase 1)-DNA crosslinks. This review summarizes the current knowledge of TEX264 as a protein with roles in both autophagy and DNA repair and provides an evolutionary and structural analysis of GyrI proteins. Based on our phylogenetic analysis, we provide evidence that TEX264 is a member of a large superfamily of GyrI-like proteins that evolved in bacteria and are present in metazoans, including invertebrates and chordates.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA