Naslov
Kleptomania - a side-effect induced by venlafaxine

Autori
Jukić, Vlado ; Makarić, Porin ; Ćurković, Marko ; Brečić, Petrana

Izvornik
International Journal of Neuropsychopharmacology (1461-1457) 19 (2016), Suppl_1; 29-30

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Kleptomania, side-effect, venlafaxine

Sažetak
Objective: Venlafaxine is a dual serotonin and norepinephrine reuptake inhibitor (SNRI), widely used as treatment of major depressive disorder (MDD), social anxiety disorder, and generalized anxiety disorder. Venalfaxine is generally considered quite effective and safe, with commonly reported adverse reactions in clinical studies being nausea, dry mouth, headache and sweating. Kleptomania is a rare impulse control disorder characterized by recurrent episodes of compulsive stealing, most commonly in the form of shoplifting. The stolen items are usually of trivial value, and not needed by the person stealing them. Kleptomanic behaviour during treatment with antidepressants was reported in several occasions, but was usually induced by serotonin selective reuptake inhibitors. Methods: We present a clinical case of a 67 years old female patient treated with venlafaxine for MDD that developed kleptomania. Results: Our patient was admitted to a psychiatric unit, presenting depressive symptoms that met ICD-10 criteria for a recurrent, severe MDD without psychotic features. Patient's leading symptoms were treated with venlafaxine and in subsequent weeks a clinically significant and subjective improvement was accomplished. After discharge, psychiatric outpatient treatment was continued. Eight months after her first hospital treatment, patient was readmitted: her depressive symptoms were recurring after she started to shoplift regularly and compulsively. As venlafaxine was discontinued and a new antidepressant, bupropion, was given, patient's compulsion vanished, leading to conclusion that kleptomania could have been induced by venlafaxine treatment. In the subsequent follow-ups, there were no signs of kleptomania. A good and stable remission of MDD was accomplished as well. Extensive diagnostic screening excluded all possible differential causes. Conclusion: So far, kleptomania as side-effect of antidepressant treatment has been reported from several different sources. Possible pathophysiological causes are further discussed, leading to the conclusion that other neurotransmitter pathways, above and beyond serotoninergic ones, can play a role in emergence of this rare and unique phenomenon.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA