Naslov
AUTOIMMUNE GASTRITIS RELATED MULTPLE GASTRIC POLYPS DIAGNOSED AS NEUROENDOCRINE TUMOR IN A SLE PATIENT

Autori
Zekić, Tatjana ; Čubranić, Aleksandar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, ostalo

Skup
12th International Congress on Autoimmunity, virtual congress

Mjesto i datum
Atena, Grčka, 28.05.2021. - 01.06.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NET, autoimmune gastritis, SLE

Sažetak
Introduction: Autoimmune gastritis (AIG) is underdiagnosed. The prevalence of gastric Neuroendocrine tumors (NETs) in Europe per 10, 000 population is estimated to be 0.32. The over-all cancer risk in SLE is slightly increased. Case presentation: A 55-year-old female patient was diagnosed with mild systemic lupus for 9 years without any major organ involvement. After 5 years she felt general weakness, fatigue. Microcytic anemia, low vitamin B12 were found while SLE was in remission. Multiple gastric polyps (about 20) of different size (< 2 cm) were verified by gastroscopy. The initial pathohistological finding indicated intestinal metaplasia, but the patient did not opt for electroresection. After 4 years a repeated biopsy of the gastric polyp was in favor of well-differentiated NET gradus 1 CgA positive Ki 67 1-2% according to 2010 WHO histologic classification. Octreoscan showed a suspected lesion in the antrum of the stomach with increased somatostatin receptor density. PET scan was negative. Anti parietal cells antibody ( APCA) was positive, levels of gastrin and gastrin 17 were high. H. pylori stool antigen was negative aswell as anti-H. pylori antibodies anti-HP-IgG. Endoscopic mucosectomia was done , 9 polyps were removed with Ki 67< 3%. Parenteral Vitamin B 12 was administered. Additionally, the patient had autoimmune thyroiditis. General prognosis is good. Conclusion: Type I gastric NETs are indolent, multifocal primary tumors. Assay of APCA, anti- intrinsic factor antibody and anti-HP-antibodies with serum gastrin (Gastrin-17) is “serological gastric biopsy”. Microcytic anemia is an earlier sign of gastric autoimmunity due to achlorhydria and pernicious anemia in advanced disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA