Naslov
N-3-Polyunsaturated Fatty Acids-Enriched Eggs Consumption Increases Serum Concentrations of E- Series Resolvins in Young Healthy Participants

Autori
Kolobarić, Nikolina ; Matić, Anita ; Šušnjara, Petar ; Mihalj, Martina ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Annals of Nutrition & Metabolism ; XII ISIN Conference on Immunonutrition July 14–16, 2021 (Online): Abstracts / - , 2021, 11-11

Skup
XII ISIN Conference on Immunonutrition

Mjesto i datum
Barcelona, Španjolska, 14.07.2021. - 16.07.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
n-3 PUFA, functional food, eicosanoids, resolvins, inflammation

Sažetak
Introduction: Western diet has lately been characterized by increased intake of n-6 PUFAs and decline in n-3 PUFAs intake1, 2 which leads to disbalance between pro- and anti-inflammatory lipid mediators synthesized from fatty acid precursors and consequently higher risk for chronic disease development3, 4. Materials and methods: Forty young healthy volunteers of both sexes, 19-28 years old, were divided into: Control group (consumed regular hen eggs) and n-3 PUFA group (consumed enriched hen eggs containing additional α-linolenic (ALA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) in edible part of hard-boiled egg). Venous blood samples were collected before and after three-weeks dietary protocol. Serum concentrations of leukotrienes (B4, B5), prostaglandins (E2, E3) and resolvin (RvE1) were measured by commercially available ELISA kits. Results: Serum concentrations of LTB5 was increased in both Control and n-3 PUFA groups after the protocol, compared to each baseline (p<0.0001 and p=0.012, respectively). RvE1 endpoint serum concentration significantly increased (p=0.013), while prostaglandin E2/E3 serum concentrations ratio significantly decreased (p=0.014) in n-3 PUFA group compared to baseline. Discussion: Our results confirm previously elaborated inhibitory effect of supplemental n-3 PUFAs on COX pathway metabolites in various cell lines5, 6, although decreased PGE2/PGE3 ratio suggests somewhat anti-inflammatory effect. Therefore, increased pro-resolving mediator RvE1 production indicates that protective effect of n- 3 PUFAs in healthy individuals is mainly exhibited through enzymatic pathways producing these metabolites. Conclusion: Anti-inflammatory effect of n-3 PUFA functional foods is manifested through higher production of pro-resolving mediators, rather than minimally inflammatory eicosanoids, in healthy population.

Izvorni jezik
Engleski

POVEZANOST RADA