Pregled bibliografske jedinice broj: 1136463
Impact of selected pesticides on cholinesterase efficiency
Impact of selected pesticides on cholinesterase efficiency // FEBS Open Bio 11 (Suppl. 1)
Ljubljana, Slovenija, 2021. str. 360-360 doi:10.1002/2211-5463.13205 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1136463 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Impact of selected pesticides on cholinesterase
efficiency
Autori
Čadež, Tena ; Kolić, Dora ; Šinko, Goran ; Liu, Yiyun ; Ma, Yongchao ; Qunhui Xie, Heidi ; Kovarik, Zrinka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
FEBS Open Bio 11 (Suppl. 1)
/ - , 2021, 360-360
Skup
45th FEBS Congress: Molecules of Life: Towards New Horizons (FEBS 2021)
Mjesto i datum
Ljubljana, Slovenija, 03.07.2021. - 08.07.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
pesticides, acetylcholinesterase, butyrylcholinesterase, oximes, inhibition, bioscavanger
(pesticides, acetylcholinesterase, butyrylcholinesterase, inhibition, oximes, bioscavanger)
Sažetak
Residual presence of pesticides in a variety of fruits, vegetables and agricultural crops nowadays can often exceed maximum residue limits. Exposure to organophosphorus pesticides through direct contact, ingestion or inhalation can have a deleterious effect on human health ; additional residue in food also contributes to the risk of exposure. The neurological system is particularly susceptible to adverse effects from either direct pesticide exposure or through food. Selected pesticides such as methamidophos, fenamiphos, ethoprophos, phosalone, and acetamiprid are pesticides with possible potential to inhibit acetylcholinesterase (AChE), the essential enzyme for neurotransmission. Disruption of AChE biosynthesis process by certain pesticides has also been evidenced, and was considered as one of the mechanisms for the long-term effects of these compounds. In order to fully understand the action of these pesticides, we investigated their effects and mechanisms on enzymatic activity of both AChE and its analog enzyme butyrylcholinesterase (BChE). The objective of this study was to reveal alterations caused by selected pesticides on the enzymatic activity and expression of AChE in selected cell lines. Moreover, a possible detoxication mechanism was tested, taking into account BChE as endogenous bioscavenger of xenobiotics.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti
POVEZANOST RADA
Projekti:
IP-2018-01-7683 - Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima (AnalyseBChE) (Kovarik, Zrinka, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
