Naslov
Folic acid tablets: dissolution testing: HPLC and UV method validation and comparasion

Autori
Mavrinac, Marina ; Štanfel, Danijela ; Kamhi Saršon, Silvia ; Lovrić, Lana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 9th Central European Symposium on Pharmaceutical Technology / - , 2012, 190-190

Skup
9th Central European Symposium of Pharmaceutical Technology (CESPT 2012)

Mjesto i datum
Dubrovnik, Hrvatska, 20.09.2012. - 22.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
folic acid ; dissolution ; UV method ; HPLC method ; comparison

Sažetak
Folic acid is a water-soluble B vitamin that plays a central role in nucleic acid biosynthesis. A lack of dietary folic acid leads to folate deficiency, which can result in many health problems, the most notable one being neural tube defects (NDTs) in developing embryos. Maternal folic acid intake during the periconceptual period is effective in reducing the occurrence of NDTs, and it has been reported that a daily supplement of 400 µg of folic acid can reduce such occurrences [1]. For this purpose, numerous synthetic folic acid supplements have been developed, one of them being folic acid tablets. It is important to know the amount of folic acid contained in a tablet that can be dissolved and delivered to a patient. Present dissolution tests for folic acid tablets regulated by the USP and BP include HPLC methods for determining the % of folic acid dissolved in time [2, 3]. Also, USP and BP dissolution tests include water as a dissolution medium, stating that folic acid is practically insoluble in water. The aim of this study was to develop and validate a more simple and less time-consuming method for determining the % of folic acid dissolved.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA