Naslov
Effect of indomethacin on somatosensory evoked potentials after experimental spinal cord injury in rabbit

Autori
Draganić, Pero ; Simonić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Periodicum biologorum 99 (1997), suppl. 1 / Vitale, Branko - Zagreb : Hrvatsko prirodoslovno društvo, 1997, 37-37

Skup
Satellite Meeting Central Nervous System : Damage and Repair

Mjesto i datum
Malinska, Hrvatska, 11.09.1997. - 13.09.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
idomethacin; somatosensory evoked potentials; spinal cord injury; rabbits

Sažetak
The effect of indomethacin on the recovery of somatosensory evoked potentials (SEPs) was evaluated in an experimental model of spinal cord impact injury in rabbits. Somatosensory evoked pontentials can provide a unique insight into the functioning of the nervous system since they result from the direct stimulation of sensory nerves. The spinal cord evoked potentials were recorded by using monopolar needle electrodes placed epidurally over the L1 and C7 segments after stimulation of the right peroneal nerve. Reference electrodes were placed in the corresponding paravertebral muscles and in a mid frontal area at Fz. The spinal cord impact injury (150 p cm) was performed under the pentob arbital anaesthesia (30 mg/kg iv.) SEPs were recorded just before the injury and eight days after the spinal cord injury. The spinal cord evoked potentials consisted of a small positive peak followed by a broad and high negative peak. Latencies of the maximal negativne peak were measured. Indomethacin, a potent inhibitor of endogenous prostaglandin synthesis was tested in the doses of 0.1; 0.3 and 1.0 mg/kg body weight (iv.). It was injected immediately after the injury and during the eight subsequent days. Spinal cord trauma provoked a latency increase of SEPs which indicate a problem in spinal conduction. Indomethacin attenuates alteration in SEPs, showing the significant effect in the dose ofd 1.0 mg/kg body weight.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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