Pregled bibliografske jedinice broj: 1130837
Egzopolisaharidi gljiva kao kontrolni agensi biosinteze aflatoksina i okratoksina A
Egzopolisaharidi gljiva kao kontrolni agensi biosinteze aflatoksina i okratoksina A, 2020., doktorska disertacija, Odjel za biologiju okoliša, Rim
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Naslov
Egzopolisaharidi gljiva kao kontrolni agensi
biosinteze aflatoksina i okratoksina A
(Mushroom exo-polysaccharides as control agents of
aflatoxin and ochratoxin A biosynthesis)
Autori
Lončar, Jelena
Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija
Fakultet
Odjel za biologiju okoliša
Mjesto
Rim
Datum
10.02
Godina
2020
Stranica
100
Mentor
Prof. dr. sc. Slaven Zjalić
Ključne riječi
aflatoksin, okratoksin A, polisaharidi gljiva
(aflatoxin, ochratoxin A, mushroom polysaccharides)
Sažetak
Mushrooms represent a formidable source of bioactive compounds. Some of these may be considered as biological response modifiers ; these include compounds with a specific biological function: antibiotics (e.g. plectasin), immune system stimulator (e, g, lentinan), antitumor agents (e.g. krestin, PSK) and hypolipidemic agents (e.g. lovastatin) inter alia. The use of a polysaccharide, Tramesan, extracted from the basidiomycete Trametes versicolor, for controlling biosynthesis of aflatoxin B1 and ochratoxin A, has been previously discussed. In this study, oligosaccharides obtained from Tramesan were evaluated. The purified exopolysaccharide of T. versicolor was partially hydrolyzed and separated by chromatography into fractions from disaccharides to heptasaccharides. Each fraction was individually tested for mycotoxin inhibition in A. flavus and A. carbonarius. Fragments smaller than seven units showed no significant effect on mycotoxin inhibition ; heptasaccharides showed inhibitory activity of up to 90% in both fungi. These results indicated that these oligosaccharides could be used as natural alternatives to crop protection chemicals for controlling these two mycotoxins. Also, the wide screening of 38 strains of different mushrooms, showed that the mushroom Schizophyllum commune (S.C. Ailanto) demonstrated the greatest inhibition of mycotoxin synthesis in A. flavus and A. carbonarius aside from Tramesan.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Integrativna bioetika (prirodne, tehničke, biomedicina i zdravstvo, biotehničke, društvene, humanističke znanosti), Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
