Naslov
Correlations between clinical and metabolic variables and smoking among antipsychotic-naïve first-episode and nonadherent chronic patients with psychosis

Autori
Huskić, Sara ; Nadalin, Sergej ; Peitl, Vjekoslav ; Karlović, Dalibor ; Zatković, Lena ; Buretić-Tomljanović, Alena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik sažetaka 10. studentskog kongresa neuroznanosti NeuRi / Beg, Vinko ; Levatić, Eva ; Delač, Ljerka ; Samardžija, Bobana - Rijeka, 2021, 118-118

Skup
10th Student Congress of Neuroscience

Mjesto i datum
Rijeka, Hrvatska; Rab, Hrvatska, 23.04.2021. - 25.04.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Antipsychotic Agents ; Psychotic Disorders ; Schizophrenia ; Smoking

Sažetak
An interaction between smoking and antipsychotic medications could potentially affect treatment efficacy, and promote metabolic side effects. Previous data are inconsistent regarding the effects of smoking on clinical psychopathology among antipsychotic-naïve or minimally medicated patients with first-episode psychosis, and there are no reports describing the effects of smoking on metabolic parameters among unmedicated patients with first-episode psychosis or chronic psychosis. Here we aimed to elucidate the influence of smoking on clinical psychopathology and metabolic parameters of psychosis among unmedicated patients. We investigated the contribution of smoking status towards Positive and Negative Syndrome Scale (PANSS) scores and metabolic syndrome-related parameters (plasma lipid and glucose concentrations, and body mass index) among two groups of unmedicated patients with psychosis from the Croatian population: antipsychotic- naïve first-episode patients and nonadherent chronic patients. Information about smoking status and antipsychotic nonadherence was obtained via self-report. PANSS data were obtained while patients were in a psychotic state during the illness requiring hospitalization. Plasma total cholesterol, LDL cholesterol, HDL cholesterol (HDL-c), triglyceride, and glucose levels were determined after a 12- hour fasting period. Compared with nonsmoking antipsychotic-naïve first- episode individuals, antipsychotic-naïve smokers exhibited significantly lower depression factor scores, and significantly higher triglyceride levels and triglyceride/HDL-c ratio (p < 0.05). Compared with nonsmoking nonadherent chronic individuals, nonadherent smokers exhibited significantly lower negative symptoms and negative factor scores, and lower HDL-c levels. Contributions of smoking to clinical and metabolic parameters ranged from ~3.4% to 10%. Our present results indicated that smoking may be a protective factor against clinical psychopathology, and a risk factor for metabolic parameters, among unmedicated patients with first-episode psychosis and chronic psychosis.

Izvorni jezik
Engleski

POVEZANOST RADA