Naslov
Systemic treatment of colorectal cancer

Autori
Šeparović, Robert ; Silovski, Tajana ; Pavlović, Mirjana ; Vazdar, Ljubica ; Pavlica, Vesna

Izvornik
Libri oncologici : Croatian journal of oncology (0300-8142) 41 (2013), 1-3; 65-72

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
colorectal cancer ; systemic therapy ; adjuvant therapy ; neoadjuvant therapy

Sažetak
Colorectal cancer is the most common type of gastrointestinal cancer. In this article treatment protocols for colon cancer are disscussed, including adjuvant and neoadjuvant therapy for resectable disease and chemotherapy for advanced or metastatic colorectal cancer. Surgery is the only curative modality for localized colorectal cancer (stage I-III). Adjuvant chemotherapy is standard for patients with stage III disease. It’s use in stage II disease is controversial, with ongoing studies seeking to confirm which markers might identify patients who would benefit. Surgical resection potentially provides the only curative option for patients with limited metastatic disease in liver and/or lung (stage IV disease). Chemotherapy rather than surgery is the standard management for metastatic disease. Biologic agents have a role in the treatment of metastatic disease, with selection increasingly guided by genetic analysis of the tumor.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA