Naslov
The performance of Cobas c311 in stat laboratory

Autori
Kutnjak, Vladimira ; Rogić, Dunja ; Fressl Juroš, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Biochemia Medica / Šimundić, Ana-Maria - Zagreb, 2012, A112-A112

Skup
2nd European Joint Congress of EFLM and UEMS

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
validation, biochemistry analyzer, stat laboratory

Sažetak
Background: The objective of this study was to perform the analytical evaluation of the biochemistry analyzer Roche Cobas c311 and compare TAT of emergency tests with biochemistry analyzer Olympus AU 480. Short validation of the Cobas c311 was performed according the guidelines of the European Committee for Laboratory standards. Materials and methods: The tested analytes in this study were : glucose, urea, creatinine, total and direct bilirubin, alpha-amylase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactat dehidrogenase, gama-glutamyltransferase, creatine kinase , lipase, C-reactive protein, calcium, sodium, potassium and chloride. Research included determination of within-run and between–run imprecision, inaccuracy, calculated total error and method comparison with Olympus AU 480. In addition, we compared tournaround time (TAT). Results: Coefficients of variation for within- run imprecision for all tested analytes were below 5%. CV's for between-day imprecision were compared to quality specifications. CVs for calcium, sodium and chloride are higher than recommended. Results for total inaccuracy (bias) revealed that urea, calcium, sodium, potassium and chloride have higher total inaccuracy than recommended. In addition, calcium, sodium and chloride are not in accordance with recommended specification when comparing total error with quality recommendations (results are higher than recommended values). Coefficients of correlation for majority of analytes were r> 0.98 except for calcium (r=0.884), sodium (r=0.837) and chloride (r=0.881). TAT for the Cobas c311 was on the average 11% longer then Olympus 480. Conclusion: Cobas c311 biochemistry analyzer is acceptable for emergency purposes, however the overall TAT is slightly longer than recommended.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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