Naslov
Aluminum-substituted Keggin germanotungstate [HAl(H2O)GeW11O39]4–: synthesis, characterization, and antibacterial activity

Autori
Tanuhadi, Elias ; Gumerova, Nadiia I. ; Prado- Roller, Alexander ; Galanski, Markus ; Čipčić- Paljetak, Hana ; Verbanac, Donatella ; Rompel, Annette

Izvornik
Inorganic chemistry (0020-1669) 60 (2021), 1; 28-31

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
polyoxometalate ; Keggin-based aluminogermanotungstate ; antibaterial activity ; Moraxella catarrhalis ; Enterococcus faecalis

Sažetak
We report on the new monosubstituted aluminum Keggin-type germanotungstate (C4H12N)4[HAlGeW11O39(H2O)]·11H2O ([Al(H2O)GeW11]4−), which has been synthesized at room temperature via rearrangement of the dilacunary [γ-GeW10O36] 8− polyoxometalate precursor. [Al(H2O)GeW11] 4− has been characterized thoroughly both in the solid state by single- crystal and powder X-ray diffraction, IR spectroscopy, thermogravimetric analysis, and elemental analysis as well as in solution by cyclic voltammetry (CV) 183W, 27Al NMR and UV−vis spectroscopy. A study on the antibacterial properties of [Al(H2O)GeW11]4− and the known aluminum(III)-centered Keggin polyoxotungstates (Al-POTs) αNa5[AlW12O40] (α- [AlW12O40]5−) and Na6[Al(AlOH2)W11O39] ([Al(AlOH2)W11O39] 6−) revealed enhanced activity for all three Al-POTs against the Gram-negative bacterium Moraxella catarrhalis (minimum inhibitory concentration (MIC) up to 4 μg mL−1 ) and the Gram-positive Enterococcus faecalis (MIC up to 128 μg mL−1 ) compared to the inactive Al(NO3)3 salt (MIC > 256 μg mL−1 ). CV indicates the redox activity of the Al- POTs as a dominating factor for the observed antibacterial activity with increased tendency to reduction, resulting in increased antibacterial activity of the POT.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija

Napomena
Bilateral financial funding was provided by
the Centre for International Cooperation &
Mobility (ICM) of
the Austrian Agency for International
Cooperation in
Education and Research (OeADGmbH) Project HR
06/
2020 to A.R. and the Project “Biological
profiling of
polyoxometalates” to Hana Čipčić Paljetak.

POVEZANOST RADA