Naslov
COVID-19 infection unmasking a previously unrecognized autoimmune blistering skin disease

Autori
Dujmović-Hasanbegović, Katarina ; Lakoš, Gordan ; Jurinović, Ksenija ; Batinac, Tanja ; Peternel, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, stručni

Skup
EADV Spring Symposium 2021

Mjesto i datum
Online, 06.05.2021. - 07.05.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
COVID-19 ; Dermatitis Herpetiformis ; Duhring's Disease ; Autoimmune Diseases

Sažetak
A 60-year-old man presented with a 3-month history of generalized rash accompanied by severe itch. Upon examination, there were excoriated papules on his trunk and extremities, more pronounced and grouped at the lower back and the extensor elbows and knees. There were also eczematous and lichenified plaques with multiple haemorrhagic crusts and excoriations present at the upper back, distal dorsal feet and the perimalleolar area of his ankles. On his palms, there multiple punctiform purpuric macules and dried vesicles. The patient reported previous history of similar lesions limited only to his hands, which occurred throughout the preceding 6 months. These were interpreted by a dermatologist as hand eczema, however, epicutaneous patch test to the standard series of contact allergens resulted negative. The patient had unsignificant previous medical history except for uncomplicated COVID-19 infection which he recovered from approximately 2-3 weeks prior to the worsening and generalization of the rash. A skin biopsy processed for histopathology revealed perivascular dermal infiltrate rich in eosinophils and neutrophils, which were additionally clustered at the dermo-epidermal junction while direct immunofluorescence of the perilesional skin showed granular IgA deposits at the tips of dermal papillae. Laboratory workup also revealed blood eosinophilia and positive antibodies to tissue transglutaminase. The patient has been diagnosed with new-onset dermatitis herpetiformis Duhring, an autoimmune blistering skin disease, which, due to the time sequence of the rash generalization, has been either triggered or unmasked by recent COVID-19 illness. Within the last year of the COVID-19 pandemic, there have been reports about the development of various post- COVID-19 autoimmune diseases. The presented case adds to the spectrum of skin diseases possibly triggered by COVID-19, which has not yet been reported in the literature.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA