Naslov
Mechanical Regulation of Epithelial Tissue Homeostasis

Autori
Kaliman, Sara ; Hubert, Maxime ; Wollnik, Carina ; Nuić, Lovro ; Vurnek, Damir ; Gehrer, Simone ; Lovrić, Jakov ; Dudziak, Diana ; Rehfeldt, Florian ; Smith, Ana-Sunčana

Izvornik
Physical review. X (2160-3308) 11 (2021); 031029, 22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
homeostasis ; epitelial tissue

Sažetak
Despite recent efforts to understand homeostasis in epithelial tissues, there are many unknowns surrounding this steady state. It is considered to be regulated by mechanoresponse, but unlike for single cells, this remains heavily debated for tissues. Here, we show that changes in matrix stiffness induce a non-equilibrium transition from tubular to squamous Madin-Darby Canine Kidney II tissues. Nonetheless, despite different cell morphologies and densities, all homeostatic tissues display equivalent topologies, which, hence, must be actively targeted and regulated. On the contrary, the mechanoresponse induces dramatic changes in the large-scale organization of the colonies. On stiff gels, this yields an unreported cooperative state of motile cells displaying higher densities than in the arrested homeostatic state. This suggests a more complex relation between cell density and motility than previously anticipated. Our results unequivocally relate the mechanosensitive properties of individual cells to the evolving macroscopic structures, an effect that could be important for understanding the emergent pathologies of living tissues.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Integrativna bioetika (prirodne, tehničke, biomedicina i zdravstvo, biotehničke, društvene, humanističke znanosti)

POVEZANOST RADA