Naslov
Association of Pentraxin-3, Galectin-3 and Matrix Metalloproteinase-9/Timp-1 with Cardiovascular Risk in Renal Disease Patients

Autori
Miljković, Milica ; Stefanović, Aleksandra ; Bogavac-Stanojević, Nataša ; Simić-Ogrizović, Sanja ; Dumić, Jerka ; Černe, Darko ; Jelić- Ivanović, Zorana ; Kotur-Stevuljević, Jelena

Izvornik
Acta clinica Croatica (0353-9466) 56 (2017), 4; 673-680

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cardiovascular diseases ; Galectin-3 ; Kidney diseases ; Matrix-metalloproteinase-9 ; Pentraxin-3 ; Tissue inhibitor of matrix metalloproteinase-1
(ardiovascular diseases ; Galectin-3 ; Kidney diseases ; Matrix-metalloproteinase-9 ; Pentraxin-3 ; Tissue inhibitor of matrix metalloproteinase-1)

Sažetak
Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre- dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin- 3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p<0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre- dialysis patients and controls (p<0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p<0.01 and p<0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.

Izvorni jezik
Engleski

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