Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents

Modrić, Marina; Božičević, Marin; Faraho, Ivan; Bosnar, Martina; Škorić, Irena

doi:10.1016/j.molstruc.2021.130526

Pregled bibliografske jedinice broj: 1122302

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents

Modrić, Marina; Božičević, Marin; Faraho, Ivan; Bosnar, Martina; Škorić, Irena

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents // Journal of molecular structure, 1239 (2021), 130526, 12 doi:10.1016/j.molstruc.2021.130526 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1122302 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents

Autori
Modrić, Marina ; Božičević, Marin ; Faraho, Ivan ; Bosnar, Martina ; Škorić, Irena

Izvornik
Journal of molecular structure (0022-2860) 1239 (2021); 130526, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thiazole ; small chemical fragments ; library design ; anti-inflammatory activity

Sažetak
Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti- inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti- inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFalpha and IL-8 release with IC50 values in µM range without cytotoxic activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.

Profili:

Irena Škorić (autor)