Naslov
Experiments and theories of aging and longevity

Autori
Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, ostalo

Izvornik
North East Wales Institute Brain Symposium 2003 / Morris, GE - Wrexham : North East Wales Institute, 2003

Skup
North East Wales Institute Brain Symposium 2003

Mjesto i datum
Wrexham, Ujedinjeno Kraljevstvo, 21.05.2003

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aging; evolution; mutation; genetic instability; telomere shortening; oxidative damage; reactive oxygen species; mitochondrial DNA mutations; cloning

Sažetak
Evolutionary theories of aging (programmed death of organisms due to limited number of somatic cell divisions, accumulated mutations, antagonistic pleiotropy, disposable soma theory), Michael Roses' fruit fly longevity experiment, critics of evolutionary theories of aging, theories of systemic aging, endocrine theories of aging, Baltimore longitudinal study of aging, progerias (Werner syndrome, Hutchinson-Guilford syndrome, Down syndrome, Cockayne syndrome, Ataxia teleangiectasia), caloric restriction, animal models of aging, Gompertz-Makeham curves, genetic instability and genetically programmed telomere shortening, oxidative damage due to reactive oxygen species, mitochondrial DNA mutations, histologic brain changes during normal aging, future prospects of aging research, including cloning.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA