Naslov
Transient expression and phosphorylation of fetal tau proteins

Autori
Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Izvornik
Third International Symposium on Normal and Abnormal Development of the Human Fetal Brain / Šimić, Goran - Zagreb, 2003, 6-6

Skup
Third International Symposium on Normal and Abnormal Development of the Human Fetal Brain

Mjesto i datum
Zagreb, Hrvatska, 13.06.2003. - 15.06.2003

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
plasticity; microtubule-associated proteins; tau; growth cone; phosphorylation; neurofibrillary degeneration; Alzheimer's disease; cerebrospinal fluid; axonal sprouting

Sažetak
Microtubule-associated proteins, neuronal growth cone composition and translocation, tau gene organization and regulation, structure of tau proteins, post-translational modifications of tau proteins, binding sites of phospho anti-tau antibodies, pattern of tau monoclonal antibodies, their epitopes, putative kinases and the respective cellular pathology, transient expression of phosphorylated fetal tau isoform in rat and human cerebral cortex, developmental regulation of fetal tau phosphorylation, predilection sites and pathway of neurofibrillary degeneration in aging and Alzheimer's disease, tau phosphorylation, mobilisation and axonal sprouting in the context of reactivation of fetal plasticity mechanisms in Alzheimer's disease, other diseases with abundant tau-positive filamentous lesions, hereditary tauopathies, neurodegenerative diagnosis through more accurate analysis of cerebrospinal fluid.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA