Pregled bibliografske jedinice broj: 111743
The role of SMN and NAIP genes in spinal muscular atrophy: Comparison of cell death features with Alzheimer's disease
The role of SMN and NAIP genes in spinal muscular atrophy: Comparison of cell death features with Alzheimer's disease // RIKEN Brain Science Institute Summer School of Neuroscience / Masao, I (ur.).
Tokyo: RIKEN Brain Science Institute, 2002. (pozvano predavanje, međunarodna recenzija, neobjavljeni rad, ostalo)
CROSBI ID: 111743 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The role of SMN and NAIP genes in spinal muscular atrophy: Comparison of cell death features with Alzheimer's disease
Autori
Šimić, Goran
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, ostalo
Izvornik
RIKEN Brain Science Institute Summer School of Neuroscience
/ Masao, I - Tokyo : RIKEN Brain Science Institute, 2002
Skup
RIKEN Brain Science Institute Summer School of Neuroscience
Mjesto i datum
Tokyo, Japan, 23.07.2002. - 02.08.2002
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
mouse model; NAIP gene; spinal muscular atrophy; SMN1 gene; SMN2 gene
Sažetak
A gene termed survival motor neuron gene (SMN) has been identified as the determining gene of SMA. In addition, a neuronal apoptosis inhibitory protein (NAIP) gene located near the SMN gene at chromosome 5 has been found deleted in more severe clinical types of the disease. A contemporary review on the regulation, expression and role of these genes in the etiopathogenesis of spinal muscular atrophy, together with the description of available mouse models of the disease, were given. In addition, differences in immunocytochemical and electron-microscopical features and kinetics of cell death between SMA and Alzheimer's disease were discussed.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
