Naslov
Neurohormones and death in systolic heart failure: keep your friends close, but your enemies closer

Autori
Borovac, Josip Anđelo

Izvornik
Heart (1355-6037) 107 (2021), 12; 945-946

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, uvodnik, stručni

Ključne riječi
heart failure ; neurohormones ; RAAS ; epinephrine ; norepinephrine ; renin ; NT-proBNP ; mortality ; cardiovascular death ; systolic heart failure ; HFrEF

Sažetak
During the past several decades, our scientific journey to understand the aetiology, progression and treatment of heart failure (HF) has been marked by a series of grand successes and bitter defeats. Although diverse types of insults to cardiomyocytes, of which injury due to myocardial infarction is the most common, can precipitate poor contractility and subsequent pump failure, it became evident that there is more to HF than only mechanical issues could account for. In earlier times, it was thought that correction of haemodynamic abnormalities will abrogate HF symptoms and progression of the disease. However, while therapeutic interventions that increased contractility or decreased peripheral vasoconstriction were often able to ameliorate symptoms and improve the haemodynamic status of a patient in a short term, the long-term outcomes remained abysmal marked by high rates of progression to end-stage disease and death. As a physiological response to impaired pump function, a complex network of peripheral arterial baroreceptors, chemoreceptors and ergoreceptors can detect circulatory deficits and activate a series of compensatory mechanisms that synergistically work to maintain cardiovascular homeostasis by augmenting cardiac contractility and heart rate, promoting water and salt retention and constricting peripheral blood vessels. This compensation is characterised by the activation of several systems such as sympathetic (adrenergic) nervous system (SNS), renin– angiotensin– aldosterone system (RAAS) and cytokine-mediated innate immunity adaptations that all contribute to cardiac repair and remodelling through endocrine, paracrine or autocrine release of biologically active molecules—neurohormones. This coordinated response of neurohormones to restore cardiac output of the failing heart is beneficial in the short term ; however, they impose deleterious effects and drive progression and exacerbation of HF.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Commissioned Editorial on the manuscript
"Norepinephrine, plasma renin activity and
cardiovascular mortality in systolic heart
failure" by Alberto Aimo et al.

POVEZANOST RADA