Pregled bibliografske jedinice broj: 1115998
Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene
Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene // Green chemistry, 20 (2018), 13; 2973-2977 doi:10.1039/c8gc01345d (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1115998 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene
Autori
Colacino, Evelina ; Porcheddu, Andrea ; Halasz, Ivan ; Charnay, Clarence ; Delogu, Francesco ; Guerra, Ruben ; Fullenwarth, Julien
Izvornik
Green chemistry (1463-9262) 20
(2018), 13;
2973-2977
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
dantrolene ; nitrofurantoin ; green-metrics ; solvent-free ; mechanochemcal
Sažetak
The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as nitrofurantoin (Furantin), dantrolene(Dantrium) and their structurally related derivatives is herein reported. Not a drop of organic solvent was used for the entire process and high yields of pure compounds were obtained without post-reaction work-up. Hydrazones were stable in the presence of water and gaseous HCl, formed as by-products during the synthesis. Comparative mechanochemical experiments were per-formed using diverse milling devices and jar materials, the active pharmaceutical ingredients were analyzed by PXRD and green metrics are calculated.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
