Naslov
Influence of the Serotonergic System Polymorphism on the Expression of Dental Anxiety

Autori
Franćeski, Tanja ; Karlović, Dalibor ; Peitl, Vjekoslav ; Ljubičić, Rudolf ; Silić, Ante ; Verzak, Željko

Izvornik
Acta clinica Croatica (0353-9466) 57. (2018), 3.; 417-423

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Anxiety ; Dental anxiety ; Polymorphism, genetic ; Serotonin plasma membrane transport proteins ; Neuroticism ; Croatia

Sažetak
SUMMARY – Th e aim of the study was to test the correlation between 5-HTTLPR polymorphism and dental anxiety. Research hypothesis was that positive relation between the expression of dental anxiety and the S allele exists in the population of healthy Caucasians. We conducted a prospective study on 159 subjects, volunteers made up of medical and non-medical staff of the Sestre milosrdnice University Hospital Centre. Both genders were included, age range 19 to 59, mentally and physically healthy (according to DSM-5 classifi cation of mental disorders). For the purpose of this research, we used a sociodemographic questionnaire containing the following information: age, gender, education level, work status, marital status and residence. Corah’s Dental Anxiety Scale- Revised (DAS-R) was used to measure dental anxiety. Data distribution was tested by Kolmogorov- Smirnov test, diff erence between the groups by χ2 -test and one-way analysis of variance, and correlation of variables by logistic regression. In the study population, we found positive correlation between S-allele and total result in DAS-R questionnaire. Th e presence of S allele suggests that the person will have a higher result in DAS-R questionnaire, i.e. higher expression of dental anxiety. Key words: Anxiety ; Dental anxiety ; Polymorphism, genetic ; Serotonin plasma membrane transport proteins ; Neuroticism ; Croatia

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA