Naslov
SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime
(SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime)

Autori
Domingues, Renato ; Lippi, Alice ; Setz, Cristian ; Outeiro, Tiago F. ; Kriško, Anita

Izvornik
Aging-US (1945-4589) 12 (2020), 18; 18778-18789

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
aging ; SARS-CoV-2 ; COVID-19 ; neuroinflammation ; inflammaging ; immunosenescence

Sažetak
Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of severe acute respiratory syndrome virus (SARS- CoV-2). Here, we discuss potential long-term consequences of SARS-CoV-2 infection, and its possibility to cause permanent damage to the immune system and the central nervous system. Advanced chronological age is one of the main risk factors for the adverse outcomes of COVID- 19, presumably due to immunosenescence and chronic low-grade inflammation, both characteristic of the elderly. The combination of viral infection and chronic inflammation in advanced chronological age might cause multiple detrimental unforeseen consequences for the predisposition and severity of neurodegenerative diseases and needs to be considered so that we can be prepared to deal with future outcomes of the ongoing pandemic.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA