Naslov
An Update on Efficacy and Safety of Emerging Hepatic Antifibrotic Agents

Autori
Rupcic Rubin, Vinka ; Bojanic, Kristina ; Smolic, Martina ; Rubin, Jurica ; Tabll, Ashraf ; Smolic, Robert

Izvornik
Journal of Clinical and Translational Hepatology (2225-0719) 9 (2021), 1; 60-70

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
: Liver fibrosis ; MAFLD ; MASH ; Clinical trials ; Antifibrotic agents ; Efficacy ; Safety

Sažetak
Liver fibrosis represents a response to chronic liver injury. Metabolic dysfunction-associated fatty liver disease and metabolic dysfunction-associated steatohepatitis are the most common chronic liver diseases, both with increasing incidence. Therefore, there is a great impetus for development of agents targeting these conditions. Accumulating data on possible treatment options for liver fibrosis are emerging in the literature. However, despite extensive research and much effort in the field, approved agents for liver fibrosis are still lacking. In this critical review, we have summarized the main data about specific treatment options for liver fibrosis gained from ongoing clinical trials, with an emphasis on efficacy and safety of these agents.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA