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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Watson, Hunna J.; Anorexia Nervosa Genetics Initiative; Yilmaz, Zeynep; Thornton, Laura M.; Hübel, Christopher; Coleman, Jonathan R. I.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M. et al.
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa // Nature Genetics, 51 (2019), 8; 1207-1214 doi:10.1038/s41588-019-0439-2 (međunarodna recenzija, članak, znanstveni)

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Naslov
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Autori
Watson, Hunna J. ; Anorexia Nervosa Genetics Initiative ; Yilmaz, Zeynep ; Thornton, Laura M. ; Hübel, Christopher ; Coleman, Jonathan R. I. ; Gaspar, Héléna A. ; Bryois, Julien ; Hinney, Anke ; Leppä, Virpi M. ; Mattheisen, Manuel ; Medland, Sarah E. ; Ripke, Stephan ; Yao, Shuyang ; Giusti- Rodríguez, Paola ; Hanscombe, Ken B. ; Purves, Kirstin L. ; Adan, Roger A. H. ; Alfredsson, Lars ; Ando, Tetsuya ; Andreassen, Ole A. ; Baker, Jessica H. ; Berrettini, Wade H. ; Boehm, Ilka ; Boni, Claudette ; Perica, Vesna Boraska ; Buehren, Katharina ; Burghardt, Roland ; Cassina, Matteo ; Cichon, Sven ; Clementi, Maurizio ; Cone, Roger D. ; Courtet, Philippe ; Crow, Scott ; Crowley, James J. ; Danner, Unna N. ; Davis, Oliver S. P. ; de Zwaan, Martina ; Dedoussis, George ; Degortes, Daniela ; DeSocio, Janiece E. ; Dick, Danielle M. ; Dikeos, Dimitris ; Dina, Christian ; Dmitrzak- Weglarz, Monika ; Docampo, Elisa ; Duncan, Laramie E. ; Egberts, Karin ; Ehrlich, Stefan ; Escaramís, Geòrgia ; Esko, Tõnu ; Estivill, Xavier ; Farmer, Anne ; Favaro, Angela ; Fernández-Aranda, Fernando ; Fichter, Manfred M. ; Fischer, Krista ; Föcker, Manuel ; Foretova, Lenka ; Forstner, Andreas J. ; Forzan, Monica ; Franklin, Christopher S. ; Gallinger, Steven ; Giegling, Ina ; Giuranna, Johanna ; Gonidakis, Fragiskos ; Gorwood, Philip ; Mayora, Monica Gratacos ; Guillaume, Sébastien ; Guo, Yiran ; Hakonarson, Hakon ; Hatzikotoulas, Konstantinos ; Hauser, Joanna ; Hebebrand, Johannes ; Helder, Sietske G. ; Herms, Stefan ; Herpertz-Dahlmann, Beate ; Herzog, Wolfgang ; Huckins, Laura M. ; Hudson, James I. ; Imgart, Hartmut ; Inoko, Hidetoshi ; Janout, Vladimir ; Jiménez-Murcia, Susana ; Julià, Antonio ; Kalsi, Gursharan ; Kaminská, Deborah ; Kaprio, Jaakko ; Karhunen, Leila ; Karwautz, Andreas ; Kas, Martien J. H. ; Kennedy, James L. ; Keski-Rahkonen, Anna ; Kiezebrink, Kirsty ; Kim, Youl-Ri ; Klareskog, Lars ; Klump, Kelly L. ; Knudsen, Gun Peggy S. ; La Via, Maria C. ; Le Hellard, Stephanie ; Levitan, Robert D. ; Li, Dong ; Lilenfeld, Lisa ; Lin, Bochao Danae ; Lissowska, Jolanta ; Luykx, Jurjen ; Magistretti, Pierre J. ; Maj, Mario ; Mannik, Katrin ; Marsal, Sara ; Marshall, Christian R. ; Mattingsdal, Morten ; McDevitt, Sara ; McGuffin, Peter ; Metspalu, Andres ; Meulenbelt, Ingrid ; Micali, Nadia ; Mitchell, Karen ; Monteleone, Alessio Maria ; Monteleone, Palmiero ; Munn-Chernoff, Melissa A. ; Nacmias, Benedetta ; Navratilova, Marie ; Ntalla, Ioanna ; O’Toole, Julie K. ; Ophoff, Roel A. ; Padyukov, Leonid ; Palotie, Aarno ; Pantel, Jacques ; Papezova, Hana ; Pinto, Dalila ; Rabionet, Raquel ; Raevuori, Anu ; Ramoz, Nicolas ; Reichborn- Kjennerud, Ted ; Ricca, Valdo ; Ripatti, Samuli ; Ritschel, Franziska ; Roberts, Marion ; Rotondo, Alessandro ; Rujescu, Dan ; Rybakowski, Filip ; Santonastaso, Paolo ; Scherag, André ; Scherer, Stephen W. ; Schmidt, Ulrike ; Schork, Nicholas J. ; Schosser, Alexandra ; Seitz, Jochen ; Slachtova, Lenka ; Slagboom, P. Eline ; Slof-Op ‘t Landt, Margarita C. T. ; Slopien, Agnieszka ; Sorbi, Sandro ; Świątkowska, Beata ; Szatkiewicz, Jin P. ; Tachmazidou, Ioanna ; Tenconi, Elena ; Tortorella, Alfonso ; Tozzi, Federica ; Treasure, Janet ; Tsitsika, Artemis ; Tyszkiewicz-Nwafor, Marta ; Tziouvas, Konstantinos ; van Elburg, Annemarie A. ; van Furth, Eric F. ; Wagner, Gudrun ; Walton, Esther ; Widen, Elisabeth ; Zeggini, Eleftheria ; Zerwas, Stephanie ; Zipfel, Stephan ; Bergen, Andrew W. ; Boden, Joseph M. ; Brandt, Harry ; Crawford, Steven ; Halmi, Katherine A. ; Horwood, L. John ; Johnson, Craig ; Kaplan, Allan S. ; Kaye, Walter H. ; Mitchell, James E. ; Olsen, Catherine M. ; Pearson, John F. ; Pedersen, Nancy L. ; Strober, Michael ; Werge, Thomas ; Whiteman, David C. ; Woodside, D. Blake ; Stuber, Garret D. ; Gordon, Scott ; Grove, Jakob ; Henders, Anjali K. ; Juréus, Anders ; Kirk, Katherine M. ; Larsen, Janne T. ; Parker, Richard ; Petersen, Liselotte ; Jordan, Jennifer ; Kennedy, Martin ; Montgomery, Grant W. ; Wade, Tracey D. ; Birgegård, Andreas ; Lichtenstein, Paul ; Norring, Claes ; Landén, Mikael ; Martin, Nicholas G. ; Mortensen, Preben Bo ; Sullivan, Patrick F. ; Breen, Gerome ; Bulik, Cynthia M. ; Eating Disorders Working Group of the Psychiatric Genomics Consortium

Izvornik
Nature Genetics (1061-4036) 51 (2019), 8; 1207-1214

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genetics ; molecular biology ; anorexia nervosa

Sažetak
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9–4% of women and 0.3% of men2, 3, 4, with twin-based heritability estimates of 50–60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8, 9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16, 992 cases of anorexia nervosa and 55, 525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Vesna Boraska Perica (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Watson, Hunna J.; Anorexia Nervosa Genetics Initiative; Yilmaz, Zeynep; Thornton, Laura M.; Hübel, Christopher; Coleman, Jonathan R. I.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M. et al.
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa // Nature Genetics, 51 (2019), 8; 1207-1214 doi:10.1038/s41588-019-0439-2 (međunarodna recenzija, članak, znanstveni)
Watson, H., Anorexia Nervosa Genetics Initiative, Yilmaz, Z., Thornton, L., Hübel, C., Coleman, J., Gaspar, H., Bryois, J., Hinney, A. & Leppä, V. (2019) Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51 (8), 1207-1214 doi:10.1038/s41588-019-0439-2.
@article{article, author = {Watson, Hunna J. and Yilmaz, Zeynep and Thornton, Laura M. and H\"{u}bel, Christopher and Coleman, Jonathan R. I. and Gaspar, H\'{e}l\'{e}na A. and Bryois, Julien and Hinney, Anke and Lepp\"{a}, Virpi M. and Mattheisen, Manuel and Medland, Sarah E. and Ripke, Stephan and Yao, Shuyang and Giusti- Rodr\'{\i}guez, Paola and Hanscombe, Ken B. and Purves, Kirstin L. and Adan, Roger A. H. and Alfredsson, Lars and Ando, Tetsuya and Andreassen, Ole A. and Baker, Jessica H. and Berrettini, Wade H. and Boehm, Ilka and Boni, Claudette and Perica, Vesna Boraska and Buehren, Katharina and Burghardt, Roland and Cassina, Matteo and Cichon, Sven and Clementi, Maurizio and Cone, Roger D. and Courtet, Philippe and Crow, Scott and Crowley, James J. and Danner, Unna N. and Davis, Oliver S. P. and de Zwaan, Martina and Dedoussis, George and Degortes, Daniela and DeSocio, Janiece E. and Dick, Danielle M. and Dikeos, Dimitris and Dina, Christian and Dmitrzak- Weglarz, Monika and Docampo, Elisa and Duncan, Laramie E. and Egberts, Karin and Ehrlich, Stefan and Escaram\'{\i}s, Ge\`{o}rgia and Esko, T\~{o}nu and Estivill, Xavier and Farmer, Anne and Favaro, Angela and Fern\'{a}ndez-Aranda, Fernando and Fichter, Manfred M. and Fischer, Krista and F\"{o}cker, Manuel and Foretova, Lenka and Forstner, Andreas J. and Forzan, Monica and Franklin, Christopher S. and Gallinger, Steven and Giegling, Ina and Giuranna, Johanna and Gonidakis, Fragiskos and Gorwood, Philip and Mayora, Monica Gratacos and Guillaume, S\'{e}bastien and Guo, Yiran and Hakonarson, Hakon and Hatzikotoulas, Konstantinos and Hauser, Joanna and Hebebrand, Johannes and Helder, Sietske G. and Herms, Stefan and Herpertz-Dahlmann, Beate and Herzog, Wolfgang and Huckins, Laura M. and Hudson, James I. and Imgart, Hartmut and Inoko, Hidetoshi and Janout, Vladimir and Jim\'{e}nez-Murcia, Susana and Juli\`{a}, Antonio and Kalsi, Gursharan and Kaminsk\'{a}, Deborah and Kaprio, Jaakko and Karhunen, Leila and Karwautz, Andreas and Kas, Martien J. H. and Kennedy, James L. and Keski-Rahkonen, Anna and Kiezebrink, Kirsty and Kim, Youl-Ri and Klareskog, Lars and Klump, Kelly L. and Knudsen, Gun Peggy S. and La Via, Maria C. and Le Hellard, Stephanie and Levitan, Robert D. and Li, Dong and Lilenfeld, Lisa and Lin, Bochao Danae and Lissowska, Jolanta and Luykx, Jurjen and Magistretti, Pierre J. and Maj, Mario and Mannik, Katrin and Marsal, Sara and Marshall, Christian R. and Mattingsdal, Morten and McDevitt, Sara and McGuffin, Peter and Metspalu, Andres and Meulenbelt, Ingrid and Micali, Nadia and Mitchell, Karen and Monteleone, Alessio Maria and Monteleone, Palmiero and Munn-Chernoff, Melissa A. and Nacmias, Benedetta and Navratilova, Marie and Ntalla, Ioanna and O’Toole, Julie K. and Ophoff, Roel A. and Padyukov, Leonid and Palotie, Aarno and Pantel, Jacques and Papezova, Hana and Pinto, Dalila and Rabionet, Raquel and Raevuori, Anu and Ramoz, Nicolas and Reichborn- Kjennerud, Ted and Ricca, Valdo and Ripatti, Samuli and Ritschel, Franziska and Roberts, Marion and Rotondo, Alessandro and Rujescu, Dan and Rybakowski, Filip and Santonastaso, Paolo and Scherag, Andr\'{e} and Scherer, Stephen W. and Schmidt, Ulrike and Schork, Nicholas J. and Schosser, Alexandra and Seitz, Jochen and Slachtova, Lenka and Slagboom, P. Eline and Slof-Op ‘t Landt, Margarita C. T. and Slopien, Agnieszka and Sorbi, Sandro and \'{S}wi\k{a}tkowska, Beata and Szatkiewicz, Jin P. and Tachmazidou, Ioanna and Tenconi, Elena and Tortorella, Alfonso and Tozzi, Federica and Treasure, Janet and Tsitsika, Artemis and Tyszkiewicz-Nwafor, Marta and Tziouvas, Konstantinos and van Elburg, Annemarie A. and van Furth, Eric F. and Wagner, Gudrun and Walton, Esther and Widen, Elisabeth and Zeggini, Eleftheria and Zerwas, Stephanie and Zipfel, Stephan and Bergen, Andrew W. and Boden, Joseph M. and Brandt, Harry and Crawford, Steven and Halmi, Katherine A. and Horwood, L. John and Johnson, Craig and Kaplan, Allan S. and Kaye, Walter H. and Mitchell, James E. and Olsen, Catherine M. and Pearson, John F. and Pedersen, Nancy L. and Strober, Michael and Werge, Thomas and Whiteman, David C. and Woodside, D. Blake and Stuber, Garret D. and Gordon, Scott and Grove, Jakob and Henders, Anjali K. and Jur\'{e}us, Anders and Kirk, Katherine M. and Larsen, Janne T. and Parker, Richard and Petersen, Liselotte and Jordan, Jennifer and Kennedy, Martin and Montgomery, Grant W. and Wade, Tracey D. and Birgeg\aard, Andreas and Lichtenstein, Paul and Norring, Claes and Land\'{e}n, Mikael and Martin, Nicholas G. and Mortensen, Preben Bo and Sullivan, Patrick F. and Breen, Gerome and Bulik, Cynthia M.}, year = {2019}, pages = {1207-1214}, DOI = {10.1038/s41588-019-0439-2}, keywords = {genetics, molecular biology, anorexia nervosa}, journal = {Nature Genetics}, doi = {10.1038/s41588-019-0439-2}, volume = {51}, number = {8}, issn = {1061-4036}, title = {Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa}, keyword = {genetics, molecular biology, anorexia nervosa} }
@article{article, author = {Watson, Hunna J. and Yilmaz, Zeynep and Thornton, Laura M. and H\"{u}bel, Christopher and Coleman, Jonathan R. I. and Gaspar, H\'{e}l\'{e}na A. and Bryois, Julien and Hinney, Anke and Lepp\"{a}, Virpi M. and Mattheisen, Manuel and Medland, Sarah E. and Ripke, Stephan and Yao, Shuyang and Giusti- Rodr\'{\i}guez, Paola and Hanscombe, Ken B. and Purves, Kirstin L. and Adan, Roger A. H. and Alfredsson, Lars and Ando, Tetsuya and Andreassen, Ole A. and Baker, Jessica H. and Berrettini, Wade H. and Boehm, Ilka and Boni, Claudette and Perica, Vesna Boraska and Buehren, Katharina and Burghardt, Roland and Cassina, Matteo and Cichon, Sven and Clementi, Maurizio and Cone, Roger D. and Courtet, Philippe and Crow, Scott and Crowley, James J. and Danner, Unna N. and Davis, Oliver S. P. and de Zwaan, Martina and Dedoussis, George and Degortes, Daniela and DeSocio, Janiece E. and Dick, Danielle M. and Dikeos, Dimitris and Dina, Christian and Dmitrzak- Weglarz, Monika and Docampo, Elisa and Duncan, Laramie E. and Egberts, Karin and Ehrlich, Stefan and Escaram\'{\i}s, Ge\`{o}rgia and Esko, T\~{o}nu and Estivill, Xavier and Farmer, Anne and Favaro, Angela and Fern\'{a}ndez-Aranda, Fernando and Fichter, Manfred M. and Fischer, Krista and F\"{o}cker, Manuel and Foretova, Lenka and Forstner, Andreas J. and Forzan, Monica and Franklin, Christopher S. and Gallinger, Steven and Giegling, Ina and Giuranna, Johanna and Gonidakis, Fragiskos and Gorwood, Philip and Mayora, Monica Gratacos and Guillaume, S\'{e}bastien and Guo, Yiran and Hakonarson, Hakon and Hatzikotoulas, Konstantinos and Hauser, Joanna and Hebebrand, Johannes and Helder, Sietske G. and Herms, Stefan and Herpertz-Dahlmann, Beate and Herzog, Wolfgang and Huckins, Laura M. and Hudson, James I. and Imgart, Hartmut and Inoko, Hidetoshi and Janout, Vladimir and Jim\'{e}nez-Murcia, Susana and Juli\`{a}, Antonio and Kalsi, Gursharan and Kaminsk\'{a}, Deborah and Kaprio, Jaakko and Karhunen, Leila and Karwautz, Andreas and Kas, Martien J. H. and Kennedy, James L. and Keski-Rahkonen, Anna and Kiezebrink, Kirsty and Kim, Youl-Ri and Klareskog, Lars and Klump, Kelly L. and Knudsen, Gun Peggy S. and La Via, Maria C. and Le Hellard, Stephanie and Levitan, Robert D. and Li, Dong and Lilenfeld, Lisa and Lin, Bochao Danae and Lissowska, Jolanta and Luykx, Jurjen and Magistretti, Pierre J. and Maj, Mario and Mannik, Katrin and Marsal, Sara and Marshall, Christian R. and Mattingsdal, Morten and McDevitt, Sara and McGuffin, Peter and Metspalu, Andres and Meulenbelt, Ingrid and Micali, Nadia and Mitchell, Karen and Monteleone, Alessio Maria and Monteleone, Palmiero and Munn-Chernoff, Melissa A. and Nacmias, Benedetta and Navratilova, Marie and Ntalla, Ioanna and O’Toole, Julie K. and Ophoff, Roel A. and Padyukov, Leonid and Palotie, Aarno and Pantel, Jacques and Papezova, Hana and Pinto, Dalila and Rabionet, Raquel and Raevuori, Anu and Ramoz, Nicolas and Reichborn- Kjennerud, Ted and Ricca, Valdo and Ripatti, Samuli and Ritschel, Franziska and Roberts, Marion and Rotondo, Alessandro and Rujescu, Dan and Rybakowski, Filip and Santonastaso, Paolo and Scherag, Andr\'{e} and Scherer, Stephen W. and Schmidt, Ulrike and Schork, Nicholas J. and Schosser, Alexandra and Seitz, Jochen and Slachtova, Lenka and Slagboom, P. Eline and Slof-Op ‘t Landt, Margarita C. T. and Slopien, Agnieszka and Sorbi, Sandro and \'{S}wi\k{a}tkowska, Beata and Szatkiewicz, Jin P. and Tachmazidou, Ioanna and Tenconi, Elena and Tortorella, Alfonso and Tozzi, Federica and Treasure, Janet and Tsitsika, Artemis and Tyszkiewicz-Nwafor, Marta and Tziouvas, Konstantinos and van Elburg, Annemarie A. and van Furth, Eric F. and Wagner, Gudrun and Walton, Esther and Widen, Elisabeth and Zeggini, Eleftheria and Zerwas, Stephanie and Zipfel, Stephan and Bergen, Andrew W. and Boden, Joseph M. and Brandt, Harry and Crawford, Steven and Halmi, Katherine A. and Horwood, L. John and Johnson, Craig and Kaplan, Allan S. and Kaye, Walter H. and Mitchell, James E. and Olsen, Catherine M. and Pearson, John F. and Pedersen, Nancy L. and Strober, Michael and Werge, Thomas and Whiteman, David C. and Woodside, D. Blake and Stuber, Garret D. and Gordon, Scott and Grove, Jakob and Henders, Anjali K. and Jur\'{e}us, Anders and Kirk, Katherine M. and Larsen, Janne T. and Parker, Richard and Petersen, Liselotte and Jordan, Jennifer and Kennedy, Martin and Montgomery, Grant W. and Wade, Tracey D. and Birgeg\aard, Andreas and Lichtenstein, Paul and Norring, Claes and Land\'{e}n, Mikael and Martin, Nicholas G. and Mortensen, Preben Bo and Sullivan, Patrick F. and Breen, Gerome and Bulik, Cynthia M.}, year = {2019}, pages = {1207-1214}, DOI = {10.1038/s41588-019-0439-2}, keywords = {genetics, molecular biology, anorexia nervosa}, journal = {Nature Genetics}, doi = {10.1038/s41588-019-0439-2}, volume = {51}, number = {8}, issn = {1061-4036}, title = {Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa}, keyword = {genetics, molecular biology, anorexia nervosa} }

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