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Pregled bibliografske jedinice broj: 1111370

PFlexAna: detecting conformational changes in remotely related proteins

Nigham, A.; Tucker-Kellogg, L.; Mihalek, I.; Verma, C.; Hsu, D.
pFlexAna: detecting conformational changes in remotely related proteins // Nucleic Acids Research, 36 (2008), Web Server; W246-W251 doi:10.1093/nar/gkn259 (međunarodna recenzija, članak, znanstveni)

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Naslov
PFlexAna: detecting conformational changes in remotely related proteins

Autori
Nigham, A. ; Tucker-Kellogg, L. ; Mihalek, I. ; Verma, C. ; Hsu, D.

Izvornik
Nucleic Acids Research (0305-1048) 36 (2008), Web Server; W246-W251

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
protein structural flexibility ; database search

Sažetak
The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into ‘super-alignments’, according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Računarstvo, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Profili:

Avatar Url Ivana Mihalek (autor)

Poveznice na cjeloviti tekst rada:

doi academic.oup.com www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Nigham, A.; Tucker-Kellogg, L.; Mihalek, I.; Verma, C.; Hsu, D.
pFlexAna: detecting conformational changes in remotely related proteins // Nucleic Acids Research, 36 (2008), Web Server; W246-W251 doi:10.1093/nar/gkn259 (međunarodna recenzija, članak, znanstveni)
Nigham, A., Tucker-Kellogg, L., Mihalek, I., Verma, C. & Hsu, D. (2008) pFlexAna: detecting conformational changes in remotely related proteins. Nucleic Acids Research, 36 (Web Server), W246-W251 doi:10.1093/nar/gkn259.
@article{article, author = {Nigham, A. and Tucker-Kellogg, L. and Mihalek, I. and Verma, C. and Hsu, D.}, year = {2008}, pages = {W246-W251}, DOI = {10.1093/nar/gkn259}, keywords = {protein structural flexibility, database search}, journal = {Nucleic Acids Research}, doi = {10.1093/nar/gkn259}, volume = {36}, number = {Web Server}, issn = {0305-1048}, title = {pFlexAna: detecting conformational changes in remotely related proteins}, keyword = {protein structural flexibility, database search} }
@article{article, author = {Nigham, A. and Tucker-Kellogg, L. and Mihalek, I. and Verma, C. and Hsu, D.}, year = {2008}, pages = {W246-W251}, DOI = {10.1093/nar/gkn259}, keywords = {protein structural flexibility, database search}, journal = {Nucleic Acids Research}, doi = {10.1093/nar/gkn259}, volume = {36}, number = {Web Server}, issn = {0305-1048}, title = {pFlexAna: detecting conformational changes in remotely related proteins}, keyword = {protein structural flexibility, database search} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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