Naslov
Comparison of proteolytic processing of Saccharomyces cerevisiae cell wall proteins Scw4 and Scw10, and their evolutionary conservation among different yeast species

Autori
Grbavac, Antonija ; Lozančić, Mateja ; Teparić, Renata ; Mrša, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEMS 2019 Abstract Book / - Glasgow : Federation of European Materials Societies (FEMS), 2019, 970-970

Skup
8th Congress of European Microbiologists (FEMS 2019)

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 07.07.2019. - 11.07.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Scw4, Scw10, cell wall, yeast

Sažetak
Scw4p, one of noncovalently bound proteins in Saccharomyces cerevisiae cell wall, undergoes complex proteolytic processing by Kex2 and yapsins. It was suggested that this proteolytic processing can influence its cell wall incorporation, given that Scw4 can form covalent bond with βglucan, and it’s possible that processing has effect on Scw4 biological activity. Scw10 shares high level of similarity with Scw4, and also contains Kex2 processing site, but it remains unclear whether Scw10 is substrate for Kex2. Both of this proteins are considered to be glucanases, although this assumption hasn’t been proven yet. Nevertheless, importance of this two proteins is indicated through extensive phenotypic changes caused by simultaneous deletion of both SCW4 and SCW10. Their evolutionary preservation among different yeast species hasn’t been investigated, however it’s noted that genomes of some other yeast species contain SCW4/SCW10 orthologs.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA