Pregled bibliografske jedinice broj: 1111254
Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
Intervertebral Disc Biology: Genetic Basis of Disc Degeneration // Current Molecular Biology Reports, 4 (2018), 4; 143-150 doi:10.1007/s40610-018-0101-2 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1111254 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Intervertebral Disc Biology: Genetic Basis of Disc
Degeneration
Autori
Munir S ; Freidin M.B ; Rade M ; Määttä J.H ; Livshits G ; Williams F.M.K
Izvornik
Current Molecular Biology Reports (2198-6428) 4
(2018), 4;
143-150
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
endplate, disc degeneration, low back pain, modic, MC, DD, Candidate genes, Heritability, GWAS, Spine
(endplate, disc degeneration, modic changes, DD, low back pain, MC, Candidate genes, Heritability, GWAS, Spine)
Sažetak
Purpose of Review This review aims to highlight recent advances in understanding the genetic basis of intervertebral disc degeneration (IDD). Recent Findings It has been known for some time that IDD is highly heritable. Recent studies, and in particular the availability of agnostic techniques such as genome-wide association studies, have identified new variants in a variety of genes which contribute to the risk of IDD and to back pain. Summary A variety of genetic variants are involved in IDD. Some are shared with variants predisposing to back pain, but few have been identified reliably in either phenotype. Further research is required to explain fully the high heritability and how the genetic variants influence cell biology to lead to IDD.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Sveučilište Jurja Dobrile u Puli,
Sveučilište J. J. Strossmayera u Osijeku
Profili:
Marinko Rade
(autor)
