Pregled bibliografske jedinice broj: 1111082
A Family of Evolution–Entropy Hybrid Methods for Ranking Protein Residues by Importance
A Family of Evolution–Entropy Hybrid Methods for Ranking Protein Residues by Importance // Journal of Molecular Biology, 336 (2004), 5; 1265-1282 doi:10.1016/j.jmb.2003.12.078 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1111082 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A Family of Evolution–Entropy Hybrid Methods for Ranking Protein Residues by Importance
Autori
Mihalek, I. ; Reš, I. ; Lichtarge, O.
Izvornik
Journal of Molecular Biology (0022-2836) 336
(2004), 5;
1265-1282
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
bioinformatics evolutionary trace information entropy functional site binding interaction, variant annotation
Sažetak
N order to identify the amino acids that determine protein structure and function it is useful to rank them by their relative importance. Previous approaches belong to two groups ; those that rely on statistical inference, and those that focus on phylogenetic analysis. Here, we introduce a class of hybrid methods that combine evolutionary and entropic information from multiple sequence alignments. A detailed analysis in insulin receptor kinase domain and tests on proteins that are well-characterized experimentally show the hybrids' greater robustness with respect to the input choice of sequences, as well as improved sensitivity and specificity of prediction. This is a further step toward proteome scale analysis of protein structure and function.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Računarstvo, Biotehnologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
