Naslov
Untargeted metabolomic profiling of serum in dogs with hypothyroidism

Autori
Muñoz-Prieto, Alberto ; González-Arostegui, Luis Guillermo ; Rubić, Ivana ; Cerón, José Joaquín ; Tvarijonaviciute, Asta ; Horvatić, Anita ; Mrljak, Vladimir

Izvornik
Research in Veterinary Science (0034-5288) 136 (2021); 6-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hypothyroidism, Dogs, Metabolomics, Endocrine, Biomarkers

Sažetak
Hypothyroidism is one of the most commonly diagnosed endocrine disease in dogs. The clinical signs are caused by a deficiency of the active thyroid hormones triiodothyronine (T3) and thyroxine (T4) and have a negative impact on dog’s quality of life. We hypothesized that serum metabolic profile varies between healthy dogs and dogs with hypothyroidism. Twenty serum samples from dogs with hypothyroidism and 20 from healthy dogs were used for untargeted metabolomics analysis performed by LC/MS analysis. Fifteen metabolites showed significant changes between hypothyroid and healthy dogs, being the pentose phosphate pathway (PPP), aminoacyl-tRNA biosynthesis and pyrimidine metabolism the principal pathways altered in hypothyroidism. Specifically, metabolites such as D-gluconic acid and L-Isoleucine may potentially act as biomarkers of disease.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA