Pregled bibliografske jedinice broj: 1110565
Magainins and the disruption of membrane-linked free-energy transduction
Magainins and the disruption of membrane-linked free-energy transduction // Proceedings of the National Academy of Sciences of the United States of America, 86 (1989), 17; 6597-6601 doi:10.1073/pnas.86.17.6597 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1110565 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Magainins and the disruption of membrane-linked
free-energy transduction
Autori
Westerhoff, Hans V. ; Juretić, Davor ; Hendler, Richard W. ; Zasloff, Michael
Izvornik
Proceedings of the National Academy of Sciences of the United States of America (0027-8424) 86
(1989), 17;
6597-6601
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
membrane-active cationic peptides ; antibiotics ; membrane potential ; antimicrobial ; oxidative phospborylation
Sažetak
Magainins, a family of positively charged peptides, are partly if not wholly responsible for antimicrobial activity in skin extracts of Xenopus laevis. We report here that members of the magainin family--i.e., the 21-amino acid peptide PGLa and the 23-amino acid peptide magainin 2 amide (PGSa)--dissipate the electric potential across various energy-transducing membranes and thus uncouple respiration from other free-energy-requiring processes. We propose that this is a likely mechanism for the antimicrobial effects of these compounds.
Izvorni jezik
Engleski
Znanstvena područja
Fizika, Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
- EconLit
