Naslov
Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria

Autori
Westerhoff, Hans V. ; Richard W Hendler, Richard, W. ; Zasloff, Michael ; Juretić, Davor

Izvornik
Biochimica et biophysica acta. Bioenergetics (0005-2728) 975 (1989), 3; 361-369

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
magainin ; vertebrate peptide antibiotics: free energy transduction ; membrane potential ; mitochondrial oxidative phosphorylation ; uncoupler ; PGLa ; X. laevis

Sažetak
Members of a newly discovered class of eukaryotic antimicrobial peptides are shownto release respiratory control in isolated rat-liver mitochondria. They also dissipate the membrane potential and inhibit respiration. The uncoupling activity of the peptides decreases with time probably due to the presence of proteases in the mitochondrial preparation. Quinine and Mg2+ reduce the activity of the peptides. The nature of the dependence of the respiratory rate on the concentration of added peptides suggests that they are active in a multimeric form, consistent with the formation of a channel across the inner mitochondrial membrane. The channel allows passage of sucrose.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija

Napomena
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BBA is abstracted and indexed by BIOSIS, Chemical
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