Naslov
Metabolomics in PTSD: Introduction and preliminary findings
(Metabolomics in PTSD: Introduction and preliminary findings)

Autori
Nedić Erjavec, Gordana ; Nikolac Perković, Matea ; Konjevod, Marcela ; Švob Štrac, Dubravka ; Tudor, Lucija ; Uzun, Suzana ; Kozumplik, Oliver ; Barbas Arribas, Coral ; Žarkovic, Neven ; Pivac, Nela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Zbornik sažetaka 9. Hrvatskog kongresa farmakologije s međunarodnim sudjelovanjem / - Zagreb : Hrvatsko društvo farmakologa, 2019, 73-73

Skup
9. hrvatski kongres farmakologije = 9th Croatian Congress of Pharmacology

Mjesto i datum
Zagreb, Hrvatska, 25.09.2019. - 28.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Posttraumatic stress disorder ; metabolomics ; metabolic profile ; glycerophospholipids ; carnitines ; bile acids

Sažetak
Introduction: Posttraumatic stress disorder (PTSD) is a severe mental disorder that develops after experiencing or witnessing traumatic or terrifying event. The exact biological factors, that contribute to vulnerability or resilience for developing PTSD after traumatic exposure, are still not well understood. Metabolomics is a new fast developing scientific discipline which allows us to study the final products of all biochemical pathways driven by genetic regulation and influenced by the environment. In the case of PTSD, one of the most important goals nowadays is to identify reliable, peripheral, non-invasive and easily accessible biomarkers that will potentiate the development of new diagnostic tests in order to early recognize, better diagnose, treat or even prevent possible development of PTSD. In metabolomics, usually this type of study starts with untargeted and non-hypothesis driven approach. Materials and methods: The aim of this study was to apply LC-MS and GC-MS based untargeted metabolomics approach to investigate a metabolic profile of patients with combat related PTSD, collected within the project „GlycoGenPTSD” supported by Croatian Science Foundation (IP-2014-09-4289). Study included plasma samples from PTSD patients (N=50) and matching controls (N=50). Results: After appropriate statistical analysis, a trend of increased levels of different types of glycerophospholipids and decreased levels of different types of carnitines and bile acids was found in PTSD subjects when compared to healthy controls. Conclusions: This preliminary study proposes metabolomics as a promising novel approach for a better understanding of PTSD etiology, but further research has to be carried out to validate current results.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA