Naslov
Mitotic spindle: lessons from theoretical modeling

Autori
Tolić, Iva M. ; Pavin, Nenad

Izvornik
Molecular biology of the cell (1059-1524) 32 (2021), 3; 218-222

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
mitotic spindle , microtubules ; kinetochores ; kinetochore fibers ; bridging fibers ; kinesins ; forces ; laser ablation ; microneedle ; theory ; modeling

Sažetak
Cell biology is immensely complex. To understand how cells work, we try to find patterns and suggest hypotheses to identify underlying mechanisms. However, it is not always easy to create a coherent picture from a huge amount of experimental data on biological systems, where the main players have multiple interactions or act in redundant pathways. In such situations, when a hypothesis does not lead to a conclusion in a direct way, theoretical modeling is a powerful tool because it allows us to formulate hypotheses in a quantitative manner and understand their consequences. A successful model should not only reproduce the basic features of the system but also provide exciting predictions, motivating new experiments. Much is learned when a model based on generally accepted knowledge cannot explain experiments of interest, as this indicates that the original hypothesis needs to be revised. In this Perspective, we discuss these points using our experiences in combining experiments with theory in the field of mitotic spindle mechanics.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA