Pregled bibliografske jedinice broj: 1107569
Purinergic receptor antagonism: A viable strategy for the management of autonomic dysreflexia?
Purinergic receptor antagonism: A viable strategy for the management of autonomic dysreflexia? // Autonomic Neuroscience, 230 (2021), 102741, 4 doi:10.1016/j.autneu.2020.102741 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 1107569 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Purinergic receptor antagonism: A viable strategy
for the management of autonomic dysreflexia?
Autori
Minic, Zeljka ; O'Leary, Donal S. ; Reynolds, Christian A.
Izvornik
Autonomic Neuroscience (1566-0702) 230
(2021);
102741, 4
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
Purinergic receptors ; Blood pressure ; Spinal cord injury ; Autonomic dysreflexia
Sažetak
The purinergic receptor ligand, ATP, may participate in reflex induced vasoconstriction through sympathetic efferent and sensory afferent mechanisms. However, the role of the purinergic system in contributing to autonomic dysreflexia following spinal cord injury is unclear. The present study investigates the involvement of P2X receptors in contributing to pressor responses during autonomic dysreflexia. Twenty rats were subjected to spinal cord injury and 24 h later hemodynamic responses to colorectal distension were recorded. Animals were randomized to receive intravenous administration of the P2X receptor antagonist, NF023, or vehicle control. The data indicate that NF023 attenuates pressor responses to colorectal distension.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
