Pregled bibliografske jedinice broj: 1106530
Auto-adaptive positive airway pressure improves lung function and arterial stiffness parameters in patients with severe obstructive sleep apnea syndrome over a 1 year follow-up
Auto-adaptive positive airway pressure improves lung function and arterial stiffness parameters in patients with severe obstructive sleep apnea syndrome over a 1 year follow-up // Physiological Measurement, 41 (2020), 12; 125006, 8 doi:10.1088/1361-6579/abcdf5 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1106530 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Auto-adaptive positive airway pressure improves
lung function and arterial stiffness parameters
in patients with severe obstructive sleep apnea
syndrome over a 1 year follow-up
Autori
Miličević, Tanja ; Katić, Josip ; Milovac Nakić, Stjepanka ; Matetić, Andrija ; Aljinović, Jure ; Đogaš, Zoran ; Gunjača, Grgo
Izvornik
Physiological Measurement (0967-3334) 41
(2020), 12;
125006, 8
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
APAP, obstructive sleep apnea, pulse wave velocity, blood pressure, end-organ damage, lung function
Sažetak
Objective: Auto-adaptive positive airway pressure (APAP)is an emerging therapeutic modality for obstructive sleep apnea (OSA) patients. However, their associated physiological effects have not been well- defined. Therefore, we aimed to investigate the impact of a 1 year APAP treatment on lung function and arterial stiffness parameters. Approach: This study enrolled male patients with newly diagnosed severe OSA who have undergone APAP treatment. A total of 35 patients completed a 1 year follow up. Blood pressure, arterial stiffness(PWV, cAIx, pAIx, cSBP), and lung function readings (FEV1, FVC, FEV1/FVC, PEF)were obtained basally and after 1, 3, 6, and 12 months of treatment. Main results: A gradual increase in FEV1 has been observed over the follow-up (2.92 ± 0.88 versus 3.07 ± 0.92 versus 3.18 ± 0.93 versus 3.28 ± 0.93 versus 3.41 ± 0.97 L), while PWV showed a gradual decrease over the follow-up (9.72 ± 1.64 versus 9.32 ± 1.73 versus 8.89 ± 1.65 versus 8.53 ± 1.61 versus 8.46 ± 1.60 m s−1 ), as measured by absolute values. Linear mixed effects model analysis revealed a statistically significantly higher FEV1 values(coefficient of 0.11, 0.20, and 0.33 for 3rd month, 6th month, and 12th month, respectively, P < 0.001) and lower PWV values(coefficient of −0.69, −0.63, and −0.34 for 3rd month, 6th month, and 12th month, respectively, P < 0.001), after the initiation of APAP treatment. Significance: We conclude that APAP treatment improves main lung function and arterial stiffness parameters in male patients with severe OSA over a 1 year follow-up.
Izvorni jezik
Engleski
POVEZANOST RADA
Ustanove:
KBC Split,
Medicinski fakultet, Split,
Sveučilište u Splitu Sveučilišni odjel zdravstvenih studija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE