Naslov
The Synthesis and crystal structures of 7-bromo-1, 3-dihydro-1-methyl-3(S)-methyl-5-(2'-pyridyl)-2H-1, 4-benzodiazepin-2-one and its Cu (II) complex

Autori
Višnjevac, Aleksandar ; Tušek-Božić, Ljerka ; Šepac, Dragan ; Hameršak, Zdenko ; Kojić-Prodić, Biserka

Izvornik
Croatica Chemica Acta (0011-1643) 76 (2003), 1; 107-112

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chiral 1; 4-benzodiazepine; copper complex; synthesis; crystal structure

Sažetak
By reaction of the enantiomerically pure 7-bromo-1, 3-dihydro-1-methyl-3(S)-methyl-5-(2'-pyridyl)-2H-1, 4-benzodiazepin-2-one, (+)-1, with CuCl2 &middot ; ; 2H2O in a mixture of absolute ethanol and dichloromethane, dichloro-[7-bromo-1, 3-dihydro-1, 3-dimethyl-5-(2'-pyridyl)-2H-1, 4-benzodiazepin-2-on-N, N, O]copper(II), (&plusmn ; ; )-2, was obtained. In both structures, characteristic boat conformation of the seven-membered benzodiazepine ring was observed. Complex 2, which was isolated as a racemic compound, revealed a slightly distorted trigonal bipyramid. Copper(II) is coordinated by two azometine nitrogen atoms, two chlorine atoms and the lactam oxygen of a neighbouring molecule. In this way an infinite chain of complex molecules was formed in the crystal. The chemical behaviour of the ligand 1 upon Cu(II) coordination was compared with its 3-hydroxymethyl and 3-acetoxymethyl analogues.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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